BH3 interacting-domain death agonist

BID
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZY3, 2BID, 2KBW, 2M5B, 2M5I, 4BD2, 4ZEQ, 5AJJ, 4QVE, 4ZIG, 4ZII, 5C3F
Identifiers
Aliases	BID, Bid, 2700049M22Rik, AI875481, AU022477, FP497, BH3 interacting domain death agonist
External IDs	OMIM: 601997; MGI: 108093; HomoloGene: 923; GeneCards: BID; OMA:BID - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q11.21 Start 17,734,138 bp[1] End 17,774,770 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 F1|6 57.02 cM Start 120,868,891 bp[2] End 120,893,814 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood granulocyte pancreatic ductal cell bone marrow right frontal lobe bone marrow cells prefrontal cortex periodontal fiber mucosa of transverse colon Top expressed in lumbar spinal ganglion granulocyte otic placode saccule stroma of bone marrow right kidney human kidney otic vesicle proximal tubule blood More reference expression data BioGPS More reference expression data
Gene ontology Molecular function death receptor binding protein binding ubiquitin protein ligase binding protein heterodimerization activity Cellular component cytoplasm membrane mitochondrial membranes mitochondrial outer membrane mitochondrion integral component of mitochondrial membrane cytosol Biological process neuron apoptotic process positive regulation of protein homooligomerization positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway extrinsic apoptotic signaling pathway signal transduction in response to DNA damage regulation of protein oligomerization establishment of protein localization to membrane protein targeting to mitochondrion regulation of mitochondrial membrane permeability involved in apoptotic process regulation of G1/S transition of mitotic cell cycle positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway regulation of cell population proliferation apoptotic mitochondrial changes positive regulation of protein oligomerization positive regulation of apoptotic process positive regulation of release of cytochrome c from mitochondria positive regulation of extrinsic apoptotic signaling pathway protein homooligomerization activation of cysteine-type endopeptidase activity involved in apoptotic process mitochondrial outer membrane permeabilization extrinsic apoptotic signaling pathway via death domain receptors hepatocyte apoptotic process release of cytochrome c from mitochondria apoptotic process regulation of apoptotic process positive regulation of mitochondrial membrane potential mitochondrial ATP synthesis coupled electron transport negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage positive regulation of fibroblast apoptotic process positive regulation of apoptotic signaling pathway negative regulation of apoptotic process positive regulation of intrinsic apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 637 12122 Ensembl ENSG00000015475 ENSMUSG00000004446 UniProt P55957 P70444 RefSeq (mRNA) NM_001196 NM_001244567 NM_001244569 NM_001244570 NM_001244572 NM_197966 NM_197967 NM_007544 RefSeq (protein) NP_001187 NP_001231496 NP_001231498 NP_001231499 NP_001231501 NP_932070 NP_932071 NP_001187.1 NP_001231496.1 NP_031570 Location (UCSC) Chr 22: 17.73 – 17.77 Mb Chr 6: 120.87 – 120.89 Mb PubMed search [3] [4]
Wikidata
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BID
human pro-apoptotic protein bid
Identifiers
Symbol	BID
Pfam	PF06393
InterPro	IPR010479
SCOP2	1ddb / SCOPe / SUPFAM
TCDB	1.A.21
OPM superfamily	40
OPM protein	2m5i
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

The BH3 interacting-domain death agonist, or BID, gene is a pro-apoptotic member of the Bcl-2 protein family.^[5] Bcl-2 family members share one or more of the four characteristic domains of homology entitled the Bcl-2 homology (BH) domains (named BH1, BH2, BH3 and BH4), and can form hetero- or homodimers. Bcl-2 proteins act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities.