BIA 10-2474

BIA 10-2474
Clinical data
Routes of
administration		Oral
Legal status
Legal status
Identifiers
  • 3-(1-(cyclohexyl(methyl)carbamoyl)-1H-imidazol-4-yl)pyridine 1-oxide
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC16H20N4O2
Molar mass300.362 g·mol−1
3D model (JSmol)
  • CN(C(=O)n1cnc(-c2ccc[n+]([O-])c2)c1)C1CCCCC1
  • InChI=1S/C16H20N4O2/c1-18(14-7-3-2-4-8-14)16(21)19-11-15(17-12-19)13-6-5-9-20(22)10-13/h5-6,9-12,14H,2-4,7-8H2,1H3
  • Key:DOWVMJFBDGWVML-UHFFFAOYSA-N

BIA 10-2474 is an experimental fatty acid amide hydrolase inhibitor developed by the Portuguese pharmaceutical company Bial-Portela & Ca. SA. It interacts with the human endocannabinoid system.[1] The drug was in development for the treatment of a range of different medical conditions from anxiety disorder to Parkinson's disease, also for the treatment of chronic pain of multiple sclerosis, cancer, hypertension or the treatment of obesity.[2] A clinical trial with this drug was underway in Rennes, France, in January 2016, in which serious adverse events occurred affecting five participants, including the death of one man.[1][3][4][5] The underlying mechanism that caused the acute neurotoxicity of this molecule remains unknown.[6][7]

  1. ^ a b Cite error: The named reference Bialstatement was invoked but never defined (see the help page).
  2. ^ "Essai thérapeutique mortel à Biotrial Rennes. Le contenu du test du Bia 10 – 2474 de Bial révélé [exclusif]". Breizh-info.com. 15 January 2016. Retrieved 17 January 2016.
  3. ^ Cite error: The named reference ANSM Statement was invoked but never defined (see the help page).
  4. ^ Cite error: The named reference Ministry Statement was invoked but never defined (see the help page).
  5. ^ Cite error: The named reference Rennes2 was invoked but never defined (see the help page).
  6. ^ Cite error: The named reference ANSMfinal was invoked but never defined (see the help page).
  7. ^ Cite error: The named reference Hinnerk was invoked but never defined (see the help page).