BNIP3

BNIP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2J5D, 2KA1, 2KA2
Identifiers
Aliases	BNIP3, NIP3, BCL2/adenovirus E1B 19kDa interacting protein 3, BCL2 interacting protein 3, HABON
External IDs	OMIM: 603293; MGI: 109326; HomoloGene: 2990; GeneCards: BNIP3; OMA:BNIP3 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q26.3 Start 131,967,684 bp[1] End 131,981,967 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F4 Start 138,492,565 bp[2] End 138,511,248 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell pons body of pancreas pars compacta right ventricle pars reticulata postcentral gyrus entorhinal cortex lateral nuclear group of thalamus dorsal motor nucleus of vagus nerve Top expressed in morula muscle of thigh proximal tubule right kidney esophagus soleus muscle quadriceps femoris muscle neural layer of retina white adipose tissue brown adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity protein binding identical protein binding protein heterodimerization activity GTPase binding Cellular component cytoplasm integral component of membrane nuclear envelope mitochondrial membranes membrane integral component of mitochondrial outer membrane nucleoplasm mitochondrial outer membrane dendrite endoplasmic reticulum mitochondrion mitochondrial envelope nucleus postsynaptic density Biological process neuron apoptotic process regulation of aerobic respiration mitochondrial fragmentation involved in apoptotic process positive regulation of mitochondrial fission response to hypoxia positive regulation of autophagy regulation of mitochondrion organization response to hyperoxia positive regulation of cardiac muscle cell apoptotic process cell death negative regulation of apoptotic process positive regulation of programmed cell death negative regulation of cell death toxin transport negative regulation of membrane potential reactive oxygen species metabolic process intrinsic apoptotic signaling pathway positive regulation of macroautophagy positive regulation of protein-containing complex disassembly cellular response to mechanical stimulus cellular response to cobalt ion regulation of mitochondrial membrane permeability autophagy of mitochondrion defense response to virus intrinsic apoptotic signaling pathway in response to hypoxia brown fat cell differentiation positive regulation of apoptotic process positive regulation of release of cytochrome c from mitochondria negative regulation of reactive oxygen species metabolic process viral process negative regulation of mitochondrial fusion granzyme-mediated apoptotic signaling pathway mitochondrial outer membrane permeabilization mitochondrial protein catabolic process autophagic cell death cellular response to hydrogen peroxide apoptotic process cardiac muscle cell apoptotic process negative regulation of mitochondrial membrane potential positive regulation of necrotic cell death cerebral cortex development oligodendrocyte differentiation positive regulation of mitochondrial calcium ion concentration cellular response to hypoxia negative regulation of mitochondrial membrane permeability involved in apoptotic process positive regulation of autophagy of mitochondrion response to bacterium Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 664 12176 Ensembl ENSG00000176171 ENSMUSG00000078566 UniProt Q12983 O55003 RefSeq (mRNA) NM_004052 NM_009760 RefSeq (protein) NP_004043 NP_033890 Location (UCSC) Chr 10: 131.97 – 131.98 Mb Chr 7: 138.49 – 138.51 Mb PubMed search [3] [4]
Wikidata
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BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 is a protein found in humans that is encoded by the BNIP3 gene.^[5]

BNIP3 is a member of the apoptotic Bcl-2 protein family. It can induce cell death while also assisting with cell survival. Like many of the Bcl-2 family proteins, BNIP3 modulates the permeability state of the outer mitochondrial membrane by forming homo- and hetero-oligomers inside the membrane.^[6] Upregulation results in a decrease in mitochondrial potential, an increase in reactive oxygen species, mitochondrial swelling and fission, and an increase in mitochondrial turnover via autophagy.^[7] Sequence similarity with Bcl-2 family members was not detected. Humans and other animals (Drosophila, Caenorhabditis), as well as lower eukaryotes (Dictyostelium, Trypanosoma, Cryptosporidium, Paramecium) encode several BNIP3 paralogues including the human NIP3L, which induces apoptosis by interacting with viral and cellular anti-apoptosis proteins.