Band 3 anion transport protein

SLC4A1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BH7, 1BNX, 1BTQ, 1BTR, 1BTS, 1BTT, 1BZK, 1HYN, 3BTB, 2BTA, 2BTB, 4KY9, 4YZF
Identifiers
Aliases	SLC4A1, solute carrier family 4 (anion exchanger), member 1 (Diego blood group), AE1, BND3, CD233, DI, EMPB3, EPB3, FR, RTA1A, SW, WD, WD1, WR, CHC, SAO, SPH4, solute carrier family 4 member 1 (Diego blood group)
External IDs	OMIM: 109270; MGI: 109393; HomoloGene: 133556; GeneCards: SLC4A1; OMA:SLC4A1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	44,268,141 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	102,257,029 bp
RNA expression pattern
	Top expressed in
	trabecular bone; ; bone marrow; ; bone marrow cells; ; renal medulla; ; blood; ; monocyte; ; kidney tubule; ; vena cava; ; glomerulus; ; human kidney;
	Top expressed in
	fetal liver hematopoietic progenitor cell; ; blood; ; tibiofemoral joint; ; human fetus; ; internal carotid artery; ; body of femur; ; external carotid artery; ; yolk sac; ; endocardial cushion; ; spleen;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; protein-membrane adaptor activity; chloride transmembrane transporter activity; transporter activity; anion transmembrane transporter activity; bicarbonate transmembrane transporter activity; protein binding; ankyrin binding; inorganic anion exchanger activity; sodium:bicarbonate symporter activity; hemoglobin binding;
Cellular component	integral component of membrane; blood microparticle; membrane; cortical cytoskeleton; plasma membrane; integral component of plasma membrane; basolateral plasma membrane; extracellular exosome; Z discdkac; cytoplasmic side of plasma membrane;
Biological process	anion transport; bicarbonate transport; cellular ion homeostasis; chloride transport; ion transport; regulation of intracellular pH; anion transmembrane transport; chloride transmembrane transport; sodium ion transmembrane transport; transport; glycolytic process; blood coagulation; plasma membrane phospholipid scrambling; negative regulation of urine volume; pH elevation; erythrocyte development; protein localization to plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	6521
	20533
	ENSG00000004939
	ENSMUSG00000006574
	P02730
	P04919
	NM_000342
	NM_011403
	NP_000333
	NP_035533
	Wikidata
View/Edit Human	View/Edit Mouse

Band 3 anion transport protein, also known as anion exchanger 1 (AE1) or band 3 or solute carrier family 4 member 1 (SLC4A1), is a protein that is encoded by the SLC4A1 gene in humans.

Band 3 anion transport protein is a phylogenetically-preserved transport protein responsible for mediating the exchange of chloride (Cl⁻) with bicarbonate (HCO₃⁻) across plasma membranes. Functionally similar members of the AE clade are AE2 and AE3.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000004939 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000006574 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Alper SL (2009). "Molecular physiology and genetics of Na+-independent SLC4 anion exchangers". Journal of Experimental Biology. 212 (11): 1672–1683. doi:10.1242/jeb.029454. PMC 2683012. PMID 19448077.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000004939 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000006574 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Alper SL (2009). "Molecular physiology and genetics of Na+-independent SLC4 anion exchangers". Journal of Experimental Biology. 212 (11): 1672–1683. doi:10.1242/jeb.029454. PMC 2683012. PMID 19448077.

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