Bartolomea Acciaioli or Acciajuoli (died around 1396) was the wife of Theodore I Palaiologos, Despot of the Morea from 1385. She was the elder daughter of Nerio I Acciaioli, who held large estates in Frankish Greece. She was famed for her beauty and her father gave her in marriage to the Despot to seal their alliance. Since her father and husband's relations deteriorated in the early 1390s, her father disinherited her in favor of her younger sister, Francesca, and their illegitimate brother, Antonio. Barolomea died childless.