The Basilica of Santa Maria Maggiore di Siponto is a church approximately three miles south of Manfredonia, Apulia, southern Italy. Once the cathedral of the city of Siponto, it received the status of Basilica Minor in 1977; it is dedicated to the Holy Virgin of Siponto (the town was moved to the new city of Manfredonia in the mid-13th century).
The church was completed around 1117, when it was consecrated (perhaps in place of a pre-existing 6th century Palaeo-Christian edifice) and the relics of Laurence of Siponto were placed under the high altar.