Benserazide

Benserazide
Clinical data
Other names	Serazide, RO 4-4602
AHFS/Drugs.com	International Drug Names
Pregnancy; category	AU: B3; ;
ATC code	None;
Identifiers
	IUPAC name (RS)-2-Amino-3-hydroxy-N′-(2,3,4-trihydroxybenzyl)propanehydrazide;
CAS Number	322-35-0 ; as HCl: 14919-77-8;
PubChem CID	2327;
IUPHAR/BPS	5150;
DrugBank	DB12783; as HCl: DBSALT002687;
ChemSpider	2237 ; as HCl: 25109;
UNII	762OS3ZEJU; as HCl: B66E5RK36Q;
KEGG	D03082 ;
ChEBI	CHEBI:64187; as HCl: CHEBI:31262;
ChEMBL	ChEMBL1096979 ; as HCl: ChEMBL1255778;
CompTox Dashboard (EPA)	DTXSID9022651 ;
Chemical and physical data
Formula	C10H15N3O5
Molar mass	257.246 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES NC(CO)C(=O)NNCC1=C(O)C(O)=C(O)C=C1;
	InChI InChI=1S/C10H15N3O5/c11-6(4-14)10(18)13-12-3-5-1-2-7(15)9(17)8(5)16/h1-2,6,12,14-17H,3-4,11H2,(H,13,18) ; Key:BNQDCRGUHNALGH-UHFFFAOYSA-N ; ; as HCl: InChI=1S/C10H15N3O5.ClH/c11-6(4-14)10(18)13-12-3-5-1-2-7(15)9(17)8(5)16;/h1-2,6,12,14-17H,3-4,11H2,(H,13,18);1H; Key:ULFCBIUXQQYDEI-UHFFFAOYSA-N;
	(verify)

Benserazide is a peripherally acting aromatic L-amino acid decarboxylase or DOPA decarboxylase inhibitor, which is unable to cross the blood–brain barrier.^[1]

^ Shen H, Kannari K, Yamato H, Arai A, Matsunaga M (March 2003). "Effects of benserazide on L-DOPA-derived extracellular dopamine levels and aromatic L-amino acid decarboxylase activity in the striatum of 6-hydroxydopamine-lesioned rats". The Tohoku Journal of Experimental Medicine. 199 (3): 149–59. doi:10.1620/tjem.199.149. PMID 12703659.
^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.