Benzydamine

Benzydamine
Clinical data
Trade names	Maxtra Gargle, Difflam, Tantum verde
AHFS/Drugs.com	International Drug Names
Pregnancy; category	AU: B2; ;
Routes of; administration	Oral, topical
ATC code	A01AD02 (WHO) ; G02CC03 (WHO); M01AX07 (WHO); M02AA05 (WHO); R02AX03 (WHO);
Legal status
Legal status	BR: Class C1 (Other controlled substances); UK: General sales list (GSL, OTC); EU: OTC;
Pharmacokinetic data
Protein binding	<20%
Elimination half-life	13 hours
Excretion	Kidney
Identifiers
	IUPAC name 3-(1-benzyl-1H-indazol-3-yloxy)-N,N-dimethylpropan-1-amine;
CAS Number	642-72-8 ;
PubChem CID	12555;
ChemSpider	12036 ;
UNII	4O21U048EF;
KEGG	D07516 ;
ChEBI	CHEBI:94563 ;
ChEMBL	ChEMBL12610 ;
CompTox Dashboard (EPA)	DTXSID7047859 ;
ECHA InfoCard	100.010.354
Chemical and physical data
Formula	C19H23N3O
Molar mass	309.413 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES n2c(OCCCN(C)C)c1ccccc1n2Cc3ccccc3;
	InChI InChI=1S/C19H23N3O/c1-21(2)13-8-14-23-19-17-11-6-7-12-18(17)22(20-19)15-16-9-4-3-5-10-16/h3-7,9-12H,8,13-15H2,1-2H3 ; Key:CNBGNNVCVSKAQZ-UHFFFAOYSA-N ;
	(verify)

Benzydamine (also known as Tantum Verde and branded in some countries as Maxtra Gargle, Difflam and Septabene), available as the hydrochloride salt, is a locally acting nonsteroidal anti-inflammatory drug (NSAID) with local anaesthetic and analgesic properties for pain relief and anti-inflammatory treatment of inflammatory conditions of the mouth and throat.^[2] It falls under class of chemicals known as indazole.

^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
^ Turnbull RS (February 1995). "Benzydamine Hydrochloride (Tantum) in the management of oral inflammatory conditions". Journal. 61 (2): 127–34. PMID 7600413.

[1] Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.

[2] Turnbull RS (February 1995). "Benzydamine Hydrochloride (Tantum) in the management of oral inflammatory conditions". Journal. 61 (2): 127–34. PMID 7600413.

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