Besipirdine

Besipirdine
Clinical data
ATC code
  • none
Legal status
Legal status
  • In general: unscheduled
Identifiers
  • N-propyl-N-(4-pyridinyl)-1H-indol-1-amine
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC16H17N3
Molar mass251.333 g·mol−1
3D model (JSmol)
  • CCCN(C1=CC=NC=C1)N2C=CC3=CC=CC=C32
  • InChI=1S/C16H17N3/c1-2-12-18(15-7-10-17-11-8-15)19-13-9-14-5-3-4-6-16(14)19/h3-11,13H,2,12H2,1H3 ☒N
  • Key:OTPPJICEBWOCKD-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Besipirdine (besipirdine hydrochloride, or HP749), an indole-substituted analog of 4-aminopyridine, is a nootropic drug developed for the treatment of Alzheimer's disease (AD).[1][2]

  1. ^ Huff FJ, Antuono PG, Delagandara JE, McDonald MA, Cutler NR, Cohen SR, et al. (1996). "A treatment and withdrawal trial of besipirdine in Alzheimer disease". Alzheimer Disease and Associated Disorders. 10 (2): 93–102. doi:10.1097/00002093-199601020-00007. PMID 8727171. S2CID 34854267.
  2. ^ Hsu RS, DiLeo EM, Chesson SM, Klein JT, Effland RC (December 1991). "Determination of HP 749, a potential therapeutic agent for Alzheimer's disease, in plasma by high-performance liquid chromatography". Journal of Chromatography. 572 (1–2): 352–359. doi:10.1016/0378-4347(91)80503-5. PMID 1818073.