Beta-2 microglobulin

B2M
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesB2M, entrez:567, IMD43, beta-2-microglobulin, Β2 microglobulin
External IDsOMIM: 109700; MGI: 88127; HomoloGene: 2987; GeneCards: B2M; OMA:B2M - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004048

NM_009735

RefSeq (protein)

NP_004039

NP_033865

Location (UCSC)Chr 15: 44.71 – 44.72 MbChr 2: 121.98 – 121.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

β2 microglobulin (B2M) is a component of MHC class I molecules. MHC class I molecules have α1, α2, and α3 proteins which are present on all nucleated cells (excluding red blood cells).[5][6] In humans, the β2 microglobulin protein[7] is encoded by the B2M gene.[6][8]

  1. ^ a b c ENSG00000273686 GRCh38: Ensembl release 89: ENSG00000166710, ENSG00000273686Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000060802Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Beta-2-microglobulin".
  6. ^ a b Güssow D, Rein R, Ginjaar I, Hochstenbach F, Seemann G, Kottman A, et al. (November 1987). "The human beta 2-microglobulin gene. Primary structure and definition of the transcriptional unit". Journal of Immunology. 139 (9): 3132–3138. doi:10.4049/jimmunol.139.9.3132. PMID 3312414. S2CID 38290153.
  7. ^ Cunningham BA, Wang JL, Berggård I, Peterson PA (November 1973). "The complete amino acid sequence of beta 2-microglobulin". Biochemistry. 12 (24): 4811–4822. doi:10.1021/bi00748a001. PMID 4586824.
  8. ^ Suggs SV, Wallace RB, Hirose T, Kawashima EH, Itakura K (November 1981). "Use of synthetic oligonucleotides as hybridization probes: isolation of cloned cDNA sequences for human beta 2-microglobulin". Proceedings of the National Academy of Sciences of the United States of America. 78 (11): 6613–6617. Bibcode:1981PNAS...78.6613S. doi:10.1073/pnas.78.11.6613. PMC 349099. PMID 6171820.