Betamethasone dipropionate

Betamethasone dipropionate
Clinical data
Trade names	Diprolene, Sernivo, Diprosone, others
Other names	Betamethasone-17,21-dipropionate
AHFS/Drugs.com	Monograph
MedlinePlus	a682799
License data	US DailyMed: Betamethasone_dipropionate;
Pregnancy; category	AU: B3; ;
Routes of; administration	Topical
ATC code	A07EA04 (WHO) C05AA05 (WHO) D07AC01 (WHO) D07XC01 (WHO) H02AB01 (WHO) R01AD06 (WHO) R03BA04 (WHO) S01BA06 (WHO) S01CB04 (WHO) S02BA07 (WHO) S03BA03 (WHO) D07CC01 (WHO) S01CA05 (WHO) S03CA06 (WHO) D07BC01 (WHO) S01BB04 (WHO);
Legal status
Legal status	AU: S4 (Prescription only); UK: POM (Prescription only); US: WARNINGRx-only;
Identifiers
	IUPAC name [(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(2-propanoyloxyacetyl)-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate;
CAS Number	5593-20-4 ;
PubChem CID	21800;
DrugBank	DBSALT000851 ; DB00443 ;
ChemSpider	20490 ;
UNII	826Y60901U;
KEGG	D01637;
ChEBI	CHEBI:31276 ;
ChEMBL	ChEMBL1200384 ;
CompTox Dashboard (EPA)	DTXSID2022672 ;
ECHA InfoCard	100.024.551
Chemical and physical data
Formula	C28H37FO7
Molar mass	504.595 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OCC(=O)[C@]3(OC(=O)CC)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)CC[C@H]4[C@@H]2C[C@@H]3C)C)C)CC;
	InChI InChI=1S/C28H37FO7/c1-6-23(33)35-15-22(32)28(36-24(34)7-2)16(3)12-20-19-9-8-17-13-18(30)10-11-25(17,4)27(19,29)21(31)14-26(20,28)5/h10-11,13,16,19-21,31H,6-9,12,14-15H2,1-5H3/t16-,19-,20-,21-,25-,26-,27-,28-/m0/s1 ; Key:CIWBQSYVNNPZIQ-XYWKZLDCSA-N ;
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Betamethasone dipropionate is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. It is applied as a topical cream, ointment, lotion or gel (Diprolene) to treat itching and other skin conditions such as eczema. Minor side effects include dry skin and mild, temporary stinging when applied.^[3] Betamethasone dipropionate is a "super high potency" corticosteroid used to treat inflammatory skin conditions such as dermatitis, eczema and psoriasis. It is a synthetic analog of the adrenal corticosteroids. Although its exact mechanism of action is not known, it is effective when applied topically to cortico-responsive inflammatory dermatoses.^[4] It is available as a generic medication.^[5]

^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
^ "Diprosone Cream - Summary of Product Characteristics (SmPC)". Electronic Medicines Compendium (EMC). Datapharm Ltd. 19 September 2019. Retrieved 14 April 2020.
^ "Betamethasone Dipropionate Side Effects". drugs.com.
^ Cite error: The named reference drugs.com was invoked but never defined (see the help page).
^ "Betamethasone Monograph for Professionals". Drugs.com. 26 December 2019. Retrieved 15 August 2020.

[FDA-AllBoxedWarnings-1] "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.

[2] "Diprosone Cream - Summary of Product Characteristics (SmPC)". Electronic Medicines Compendium (EMC). Datapharm Ltd. 19 September 2019. Retrieved 14 April 2020.

[brand-3] "Betamethasone Dipropionate Side Effects". drugs.com.

[drugs.com-4] Cite error: The named reference drugs.com was invoked but never defined (see the help page).

[5] "Betamethasone Monograph for Professionals". Drugs.com. 26 December 2019. Retrieved 15 August 2020.

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