Betamethasone valerate

Betamethasone valerate
Clinical data
Trade names	Betnovate, Celestoderm, Ecoval 70, Hormezon
Other names	Betamethasone 17-valerate
AHFS/Drugs.com	Monograph
Drug class	Corticosteroid; glucocorticoid
Legal status
Legal status	US: WARNING;
Identifiers
	IUPAC name (11β,16β)-9-Fluoro-11,21-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl valerate;
CAS Number	2152-44-5;
PubChem CID	16533;
ChemSpider	15673;
UNII	9IFA5XM7R2;
ChEBI	CHEBI:31277 ;
ChEMBL	ChEMBL1497 ;
CompTox Dashboard (EPA)	DTXSID7022673 ;
ECHA InfoCard	100.016.764
Chemical and physical data
Formula	C27H37FO6
Molar mass	476.585 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCCC(=O)O[C@@]1([C@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2CCC4=CC(=O)C=C[C@@]43C)F)O)C)C)C(=O)CO;
	InChI InChI=1S/C27H37FO6/c1-5-6-7-23(33)34-27(22(32)15-29)16(2)12-20-19-9-8-17-13-18(30)10-11-24(17,3)26(19,28)21(31)14-25(20,27)4/h10-11,13,16,19-21,29,31H,5-9,12,14-15H2,1-4H3/t16-,19-,20-,21-,24-,25-,26-,27-/m0/s1 ; Key:SNHRLVCMMWUAJD-SUYDQAKGSA-N ;

Betamethasone valerate is a synthetic glucocorticoid ester. It is the 17-valerate ester of betamethasone.^[2]^[3] Betamethasone valerate is often used to treat mild eczema with good efficacy and lower incidence of steroid induced adverse effects due to its lower potency compared to other glucocorticoids.^[4] Betamethasone-17-valerate is available in cream, ointment, lotion, and foam preparations for topical use.^[4]^[5]^[6]

^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
^ Ly S, Amici JM (2018). "Role of betamethasone valerate 2.250 mg medicated plaster in the treatment of psoriasis and other dermatological pathologies: a review". Drugs in Context. 7: 212539. doi:10.7573/dic.212539. PMC 6104053. PMID 30151017.
^ "Betamethasole valerate". PubChem. U.S. National Library of Medicine.
^ ^a ^b Raveendran R (November 2019). "Tips and Tricks for Controlling Eczema". Immunology and Allergy Clinics of North America. 39 (4): 521–533. doi:10.1016/j.iac.2019.07.006. PMID 31563186. S2CID 202816063.
^ Payne J, Habet KA, Pona A, Feldman SR (August 2019). "A Review of Topical Corticosteroid Foams". Journal of Drugs in Dermatology. 18 (8): 756–770. PMID 31424707.
^ Duweb GA, Abuzariba O, Rahim M, al-Taweel M, Abdulla SA (2000). "Scalp psoriasis: topical calcipotriol 50 micrograms/g/ml solution vs. betamethasone valerate 1% lotion". International Journal of Clinical Pharmacology Research. 20 (3–4): 65–68. PMID 11314240.

[FDA-AllBoxedWarnings-1] "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.

[2] Ly S, Amici JM (2018). "Role of betamethasone valerate 2.250 mg medicated plaster in the treatment of psoriasis and other dermatological pathologies: a review". Drugs in Context. 7: 212539. doi:10.7573/dic.212539. PMC 6104053. PMID 30151017.

[3] "Betamethasole valerate". PubChem. U.S. National Library of Medicine.

[:0-4] Raveendran R (November 2019). "Tips and Tricks for Controlling Eczema". Immunology and Allergy Clinics of North America. 39 (4): 521–533. doi:10.1016/j.iac.2019.07.006. PMID 31563186. S2CID 202816063.

[5] Payne J, Habet KA, Pona A, Feldman SR (August 2019). "A Review of Topical Corticosteroid Foams". Journal of Drugs in Dermatology. 18 (8): 756–770. PMID 31424707.

[6] Duweb GA, Abuzariba O, Rahim M, al-Taweel M, Abdulla SA (2000). "Scalp psoriasis: topical calcipotriol 50 micrograms/g/ml solution vs. betamethasone valerate 1% lotion". International Journal of Clinical Pharmacology Research. 20 (3–4): 65–68. PMID 11314240.

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