Big Creek is a stream in southern Madison and northeastern Wayne counties the U.S. state of Missouri.[1] It is a tributary of the Castor River.[2]
The stream headwaters are at the confluence of the East Fork Big Creek and Middle Fork Big Creek just south of Buckhorn in Madison County at 37°20′03″N 90°17′35″W / 37.33417°N 90.29306°W. The stream flows southeast parallel to Missouri Route M into Wayne County. The stream flows past the communities of Cascade and Gravelton where it turns easterly to enter the Castor River one half mile from the Wayne-Bollinger county line at 37°17′23″N 90°13′39″W / 37.28972°N 90.22750°W.[1][2][3]
Big Creek was named so because it is large relative to other nearby creeks.[4]