| Conference | MSHSAA |
|---|---|
| Commissioner | N/A |
| No. of teams | 8 |
| Region | Southeast Missouri |
The Big Spring Conference is a high school athletic conference comprising small-size high schools located in southeast Missouri. The conference members are located in the counties of Carter, Oregon, Reynolds, Shannon, and Texas. It is named after the Big Spring in the Current River that flows through much of the area and many of the counties in the conference.