Bik Kwoon Tye

Bik K Tye
Bik Kwoon Tye
Alma materWellesley College (B.A)

University of California, San Francisco (UCSF) (M.Sc.)

Massachusetts Institute of Technology (Ph.D.)
Known forOkazaki fragment generation during aberrant DNA repair in E. coli, Minichromosome maintenance genes (MCM) in yeast, High-resolution structures of MCM complexes and origin recognition complex (ORC)
SpouseHenry Sze-Hoi Tye
Children2
AwardsHelen Hay Whitney Postdoctoral Research Fellowship (1974–1977). Elected to the National Academy of Sciences (2023).
Scientific career
FieldsMolecular Genetics, Structural Biology
InstitutionsCornell University, Hong Kong University of Science & Technology
Doctoral advisorDavid Botstein and Joel Huberman

Bik Kwoon Yeung Tye (Chinese: 戴楊碧瓘; born c. 1947) is a Chinese-American molecular geneticist and structural biologist. Tye's pioneering work on eukaryotic DNA replication led to the discovery of the minichromosome maintenance (MCM) genes in 1984,[1] which encode the catalytic core of the eukaryotic replisome. Tye also determined the first high-resolution structures of both the MCM complex[2] and the Origin Recognition Complex (ORC)[3] in 2015 and 2018. Tye is currently a Professor Emeritus (2015) at Cornell University[4] and a visiting professor at the Hong Kong University of Science & Technology.[5] She is married to Henry Sze-Hoi Tye and is the mother of Kay Tye[6] and Lynne Tye.[7]

  1. ^ Tye, Bik-Kwoon; Sinha, Pratima; Maine, Gregory T. (1984-03-01). "Mutants of S. Cerevisiae Defective in the Maintenance of Minichromosomes". Genetics. 106 (3): 365–385. doi:10.1093/genetics/106.3.365. ISSN 0016-6731. PMC 1224244. PMID 6323245.
  2. ^ Gao, Ning; Tye, Bik-Kwoon; Lei, Jianlin; Maojun Yang; Li, Wanqiu; Zhang, Yixiao; Zhai, Yuanliang; Li, Ningning (August 2015). "Structure of the eukaryotic MCM complex at 3.8 Å". Nature. 524 (7564): 186–191. Bibcode:2015Natur.524..186L. doi:10.1038/nature14685. ISSN 1476-4687. PMID 26222030. S2CID 4468690.
  3. ^ Tye, Bik-Kwoon; Gao, Ning; Zhao, Yongqian; Cheng, Erchao; Cheng, Jiaxuan; Zhai, Yuanliang; Lam, Wai Hei; Li, Ningning (July 2018). "Structure of the origin recognition complex bound to DNA replication origin". Nature. 559 (7713): 217–222. Bibcode:2018Natur.559..217L. doi:10.1038/s41586-018-0293-x. ISSN 1476-4687. PMID 29973722. S2CID 49577101.
  4. ^ "Emeriti Faculty | Department of Molecular Biology and Genetics". mbg.cornell.edu. Retrieved 2019-08-04.
  5. ^ "Bik-Kwoon YEUNG TYE". The Hong Kong University of Science and Technology. Retrieved 4 August 2019.
  6. ^ Schaffer, Amanda. "Homing in on how the brain helps us seek pleasure and avoid pain". MIT Technology Review. Retrieved 2019-08-23.
  7. ^ "A 70yo's secret to a full and happy life". Keyv values blog. Retrieved 21 November 2019.