Bile salt-dependent lipase

CEL
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1F6W, 1JMY
Identifiers
Aliases	CEL, BAL, BSDL, BSSL, CELL, CEase, FAP, FAPP, LIPA, MODY8, Bile salt-dependent lipase, carboxyl ester lipase
External IDs	OMIM: 114840; MGI: 88374; HomoloGene: 37529; GeneCards: CEL; OMA:CEL - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	133,071,861 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	28,453,415 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; beta cell; ; pituitary gland; ; anterior pituitary; ; corpus epididymis; ; caput epididymis; ; duodenum; ; right hemisphere of cerebellum; ; right uterine tube; ; paraflocculus of cerebellum;
	Top expressed in
	pyloric antrum; ; islet of Langerhans; ; lactiferous gland; ; epithelium of stomach; ; duodenum; ; sexually immature organism; ; mucous cell of stomach; ; migratory enteric neural crest cell; ; embryo; ; tracheobronchial tree;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	heparin binding; acylglycerol lipase activity; catalytic activity; protein binding; hydrolase activity; hydrolase activity, acting on ester bonds; carboxylic ester hydrolase activity; triglyceride lipase activity; sterol esterase activity; signaling receptor activity; neurexin family protein binding;
Cellular component	cytoplasm; extracellular region; extracellular exosome; extracellular space; integral component of plasma membrane; cell surface; synapse; presynapse;
Biological process	fatty acid catabolic process; lipid digestion; protein esterification; lipid metabolism; cholesterol catabolic process; pancreatic juice secretion; intestinal lipid catabolic process; lipid catabolic process; intestinal cholesterol absorption; triglyceride metabolic process; neuron cell-cell adhesion; synaptic vesicle endocytosis; modulation of chemical synaptic transmission; postsynaptic membrane assembly; presynaptic membrane assembly;
	Sources:Amigo / QuickGO
Orthologs
	1056
	12613
	ENSG00000170835
	ENSMUSG00000026818
	P19835
	Q64285
	NM_001807
	NM_009885
	NP_001798
	NP_034015
	Wikidata
View/Edit Human	View/Edit Mouse

Bile salt-dependent lipase (or BSDL), also known as carboxyl ester lipase (or CEL) is an enzyme produced by the adult pancreas and aids in the digestion of fats. Bile salt-stimulated lipase (or BSSL) is an equivalent enzyme found within breast milk. BSDL has been found in the pancreatic secretions of all species in which it has been looked for. BSSL, originally discovered in the milk of humans and various other primates, has since been found in the milk of many animals including dogs, cats, rats, and rabbits.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170835 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026818 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Swan JS, Hoffman MM, et al. (1992). "Two forms of human milk bile-salt-stimulated lipase". Biochem. J. 283 (1): 119–122. doi:10.1042/bj2830119. PMC 1131002. PMID 1567358.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170835 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026818 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Swan JS, Hoffman MM, et al. (1992). "Two forms of human milk bile-salt-stimulated lipase". Biochem. J. 283 (1): 119–122. doi:10.1042/bj2830119. PMC 1131002. PMID 1567358.

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