Biperiden

Biperiden
Clinical data
Trade namesAkineton
AHFS/Drugs.comMonograph
MedlinePlusa699058
License data
Pregnancy
category
  • AU: B2
Routes of
administration		By mouth, intramuscular injection (IM), intravenous therapy (IV)
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability33 ± 5% (by mouth)
Protein binding60%
MetabolismLiver hydroxylation
Elimination half-life18 to 24 hours
ExcretionKidney
Identifiers
  • (1RS,2SR,4RS)-1-(bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piperidin- 1-yl)propan-1-ol
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.007.441 Edit this at Wikidata
Chemical and physical data
FormulaC21H29NO
Molar mass311.469 g·mol−1
3D model (JSmol)
  • OC(c1ccccc1)(CCN2CCCCC2)C4C3\C=C/C(C3)C4
  • InChI=1S/C21H29NO/c23-21(19-7-3-1-4-8-19,11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17/h1,3-4,7-10,17-18,20,23H,2,5-6,11-16H2 checkY
  • Key:YSXKPIUOCJLQIE-UHFFFAOYSA-N checkY
  (verify)

Biperiden, sold under the brand name Akineton among others, is a medication used to treat Parkinson disease, certain drug-induced movement disorders[2] and Tourette Syndrome[citation needed]. It is not recommended for tardive dyskinesias.[3] It is taken by mouth, injection into a vein, or muscle.[2][3]

Common side effects include blurred vision, dry mouth, sleepiness, constipation, and confusion.[2] It should not be used in people with a bowel obstruction or glaucoma.[2] It is unclear if use in pregnancy or breastfeeding is safe.[4] Biperiden is in the anticholinergic family of medication.[2]

Biperiden was approved for medical use in the United States in 1959.[2] It is on the World Health Organization's List of Essential Medicines.[5] Biperiden is no longer marketed in the United States.[6][7][8]

  1. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  2. ^ a b c d e f "Biperiden Hydrochloride". The American Society of Health-System Pharmacists. Archived from the original on 21 December 2016. Retrieved 8 December 2016.
  3. ^ a b World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 243. hdl:10665/44053. ISBN 9789241547659.
  4. ^ "Biperiden Use During Pregnancy | Drugs.com". www.drugs.com. Archived from the original on 21 December 2016. Retrieved 15 December 2016.
  5. ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  6. ^ "Akineton (biperiden hydrochloride): FDA-Approved Drugs". U.S. Food and Drug Administration. Retrieved 2 July 2020.
  7. ^ "Akineton (biperiden lactate): FDA-Approved Drugs". U.S. Food and Drug Administration. Retrieved 2 July 2020.
  8. ^ "Akineton Tablets (biperiden hydrochloride)". DailyMed. Retrieved 2 July 2020.