| Blanc chloromethylation | |
|---|---|
| Named after | Gustave Louis Blanc |
| Reaction type | Substitution reaction |
| Identifiers | |
| Organic Chemistry Portal | blanc-reaction |
The Blanc chloromethylation (also called the Blanc reaction) is the chemical reaction of aromatic rings with formaldehyde and hydrogen chloride to form chloromethyl arenes. The reaction is catalyzed by Lewis acids such as zinc chloride.[1] The reaction was discovered by Gustave Louis Blanc (1872-1927) in 1923.[2][3]
- ^ Belen'kii, Leonid I; Vol'kenshtein, Yu B; Karmanova, I B (30 September 1977). "New Data on the Chloromethylation of Aromatic and Heteroaromatic Compounds". Russian Chemical Reviews. 46 (9): 891–903. Bibcode:1977RuCRv..46..891B. doi:10.1070/RC1977v046n09ABEH002180. S2CID 250898192.
- ^ Blanc, Gustave Louis (1923). "Sur la préparation de dérivés chlorométhyléniques aromatiques". Bulletin de la Société Chimique de France. Série 4. 33: 313–319.
- ^ Grassi, G.; Maselli, C. (1898). "Su alcuni derivati clorurati de trossimetilene" [On some chlorinated derivatives of 1,3,5-trioxane]. Gazzetta Chimica Italiana. 28 (pt 2): 477–500 [495].