Blepharospasm

Blepharospasm
Other namesEye dystonia, Eye twitching, Eye spasm
Pronunciation
SpecialtyNeurology, ophthalmology

Blepharospasm is a neurological disorder characterized by intermittent, involuntary spasms and contractions of the orbicularis oculi (eyelid) muscles around both eyes.[1][2][3][4] These result in abnormal twitching or blinking, and in the extreme, sustained eyelid closure resulting in functional blindness.

The word blepharospasm is derived from the Greek: βλέφαρον / blepharon, eyelid, and σπασμός / spasmos, spasm, an uncontrolled muscle contraction. The condition should be distinguished from the more common, and milder, involuntary quivering of an eyelid, known as myokymia or fasciculation.

Blepharospasm is one form of a group of movement disorders called dystonia.[4] It may be a primary or secondary disorder. The primary disorder is benign essential blepharospasm, in which term the qualifier essential indicates that the cause is unknown. Blepharospasm may occur as secondary to conditions including dry eyes and other specific ocular disease or conditions, Meige's Syndrome and other forms of dystonia, and Parkinson's Disease and other movement disorders.[3]

Blepharospasm occurs in middle age and is more frequent among women than men. The most common treatments are medication and periodic injections of botulinum toxin into the eyelid muscles.

  1. ^ Hallett, Mark (12 November 2002). "Blepharospasm: Recent advances". Neurology. 59 (9): 1306–1312. doi:10.1212/01.WNL.0000027361.73814.0E. ISSN 0028-3878. PMID 12434791.
  2. ^ Hallett, Mark; Evinger, Craig; Jankovic, Joseph; Stacy, Mark (14 October 2008). "Update on blepharospasm". Neurology. 71 (16): 1275–1282. doi:10.1212/01.wnl.0000327601.46315.85. ISSN 0028-3878. PMC 2676990. PMID 18852443.
  3. ^ a b Defazio, Giovanni; Hallett, Mark; Jinnah, Hyder A.; Conte, Antonella; Berardelli, Alfredo (10 February 2017). "Blepharospasm 40 years later". Movement Disorders. 32 (4): 498–509. doi:10.1002/mds.26934. ISSN 0885-3185. PMC 5941939. PMID 28186662.
  4. ^ a b Scorr, Laura M.; Cho, Hyun Joo; Kilic-Berkmen, Gamze; McKay, J. Lucas; Hallett, Mark; Klein, Christine; Baumer, Tobias; Berman, Brian D.; Feuerstein, Jeanne S.; Perlmutter, Joel S.; Berardelli, Alfredo; Ferrazzano, Gina; Wagle-Shukla, Aparna; Malaty, Irene A.; Jankovic, Joseph (16 May 2022). "Clinical Features and Evolution of Blepharospasm: A Multicenter International Cohort and Systematic Literature Review". Dystonia. 1. doi:10.3389/dyst.2022.10359. ISSN 2813-2106. PMC 9557246. PMID 36248010.