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"Bo Knows" was an advertising campaign for Nike cross-training shoes that ran in 1989 and 1990 and featured professional baseball and American football player Bo Jackson. It was also used as an advertising campaign for EA Sports' Madden NFL 22.
Jackson was the first athlete in the modern era to play professional baseball and football in the same year. He was a suitable spokesman for Nike's shoe geared toward an athlete engaged in more than one sport or with little time between activities to switch to sport-specific footwear.