Bone metastasis

Bone metastasis
3D rendered CT scan of bone metastases of the hip bone, in a 60 year old woman with parotid gland cancer. Large lesions are seen on the ilium on the more distant side. Involvement of the vertebral column has caused a compression fracture.
SpecialtyOncology

Bone metastasis, or osseous metastatic disease, is a category of cancer metastases that result from primary tumor invasions into bones. Bone-originating primary tumors such as osteosarcoma, chondrosarcoma, and Ewing sarcoma are rare; the most common bone tumor is a metastasis.[1] Bone metastases can be classified as osteolytic, osteoblastic, or both. Unlike hematologic malignancies which originate in the blood and form non-solid tumors, bone metastases generally arise from epithelial tumors and form a solid mass inside the bone. Primary breast cancer patients are particularly vulnerable to develop bone metastases.[2] Bone metastases, especially in a state of advanced disease, can cause severe pain, characterized by a dull, constant ache with periodic spikes of incident pain.[3]

  1. ^ MedlinePlus Overview bonecancer
  2. ^ Wang Y, Zhan X, et al. (January 22, 2024). "Siglec-15/sialic acid axis as a central glyco-immune checkpoint in breast cancer bone metastasis". Proceedings of the National Academy of Sciences of the United States of America. 121 (5): e2312929121. doi:10.1073/pnas.2312929121. PMC 10835054. PMID 38252825.
  3. ^ Jimenez-Andrade JM, Mantyh WG, Bloom AP, Ferng AS, Geffre CP, Mantyh PW (June 2010). "Bone cancer pain". Annals of the New York Academy of Sciences. 1198 (1): 173–81. Bibcode:2010NYASA1198..173J. doi:10.1111/j.1749-6632.2009.05429.x. PMC 5642911. PMID 20536932.