Bone morphogenetic protein 3, also known as osteogenin, is a protein in humans that is encoded by the BMP3 gene.[5]
The protein encoded by this gene is a member of the transforming growth factor beta superfamily. It, unlike other bone morphogenetic proteins (BMP's) inhibits the ability of other BMP's to induce bone and cartilage development. It is a disulfide-linked homodimer. It negatively regulates bone density. BMP3 is an antagonist to other BMP's in the differentiation of osteogenic progenitors. It is highly expressed in fractured tissues.