Bone sialoprotein

IBSP
Identifiers
Aliases	IBSP, BNSP, BSP, BSP-II, SP-II, integrin binding sialoprotein
External IDs	OMIM: 147563; MGI: 96389; HomoloGene: 3644; GeneCards: IBSP; OMA:IBSP - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	87,812,435 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	104,459,335 bp
RNA expression pattern
	Top expressed in
	tibia; ; periodontal fiber; ; trabecular bone; ; amniotic fluid; ; mucosa of paranasal sinus; ; frontal pole; ; middle frontal gyrus; ; muscle of trunk; ; Skeletal muscle tissue of rectus abdominis; ; cerebellar vermis;
	Top expressed in
	body of femur; ; calvaria; ; fossa; ; human fetus; ; tibiofemoral joint; ; molar; ; condyle; ; stroma of bone marrow; ; ankle; ; mandible;
	More reference expression data
	n/a
Gene ontology
Molecular function	integrin binding; molecular function;
Cellular component	extracellular matrix; extracellular region; membrane; extracellular space; vesicle;
Biological process	biomineral tissue development; bone mineralization; cellular response to growth factor stimulus; cell adhesion; extracellular matrix organization; osteoblast differentiation; ossification; positive regulation of cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	3381
	15891
	ENSG00000029559
	ENSMUSG00000029306
	P21815
	Q61711
	NM_004967
	NM_008318
	NP_004958
	NP_032344
	Wikidata
View/Edit Human	View/Edit Mouse

Bone sialoprotein (BSP) is a component of mineralized tissues such as bone, dentin, cementum and calcified cartilage. BSP is a significant component of the bone extracellular matrix and has been suggested to constitute approximately 8% of all non-collagenous proteins found in bone and cementum.^[5] BSP, a SIBLING protein, was originally isolated from bovine cortical bone as a 23-kDa glycopeptide with high sialic acid content.^[6]^[7]

The human variant of BSP is called bone sialoprotein 2 also known as cell-binding sialoprotein or integrin-binding sialoprotein and is encoded by the IBSP gene.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000029559 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029306 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fisher LW, McBride OW, Termine JD, Young MF (February 1990). "Human bone sialoprotein. Deduced protein sequence and chromosomal localization". J. Biol. Chem. 265 (4): 2347–51. doi:10.1016/S0021-9258(19)39982-X. PMID 2404984.
^ Williams PA, Peacocke AR (November 1965). "The physical properties of a glycoprotein from bovine cortical bone (bone sialoprotein)". Biochim. Biophys. Acta. 101 (3): 327–35. doi:10.1016/0926-6534(65)90011-4. PMID 5862222.
^ Herring GM (February 1964). "Comparison of bovine bone sialoprotein and serum orosomucoid". Nature. 201 (4920): 709. Bibcode:1964Natur.201..709H. doi:10.1038/201709a0. PMID 14139700. S2CID 4210187.
^ Kerr JM, Fisher LW, Termine JD, Wang MG, McBride OW, Young MF (August 1993). "The human bone sialoprotein gene (IBSP): genomic localization and characterization". Genomics. 17 (2): 408–15. doi:10.1006/geno.1993.1340. PMID 8406493.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000029559 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029306 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2404984-5] Fisher LW, McBride OW, Termine JD, Young MF (February 1990). "Human bone sialoprotein. Deduced protein sequence and chromosomal localization". J. Biol. Chem. 265 (4): 2347–51. doi:10.1016/S0021-9258(19)39982-X. PMID 2404984.

[pmid5862222-6] Williams PA, Peacocke AR (November 1965). "The physical properties of a glycoprotein from bovine cortical bone (bone sialoprotein)". Biochim. Biophys. Acta. 101 (3): 327–35. doi:10.1016/0926-6534(65)90011-4. PMID 5862222.

[pmid14139700-7] Herring GM (February 1964). "Comparison of bovine bone sialoprotein and serum orosomucoid". Nature. 201 (4920): 709. Bibcode:1964Natur.201..709H. doi:10.1038/201709a0. PMID 14139700. S2CID 4210187.

[pmid8406493-8] Kerr JM, Fisher LW, Termine JD, Wang MG, McBride OW, Young MF (August 1993). "The human bone sialoprotein gene (IBSP): genomic localization and characterization". Genomics. 17 (2): 408–15. doi:10.1006/geno.1993.1340. PMID 8406493.

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