| Pancreatic ribonuclease | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Structure of RNase A | |||||||||
| Identifiers | |||||||||
| EC no. | 3.1.27.5 | ||||||||
| CAS no. | 9001-99-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Bovine pancreatic ribonuclease, also often referred to as bovine pancreatic ribonuclease A or simply RNase A, is a pancreatic ribonuclease enzyme that cleaves single-stranded RNA. Bovine pancreatic ribonuclease is one of the classic model systems of protein science.[1] Two Nobel Prizes in Chemistry have been awarded in recognition of work on bovine pancreatic ribonuclease: in 1972, the Prize was awarded to Christian Anfinsen for his work on protein folding and to Stanford Moore and William Stein for their work on the relationship between the protein's structure and its chemical mechanism;[2] in 1984, the Prize was awarded to Robert Bruce Merrifield for development of chemical synthesis of proteins.[3]
- ^ Raines RT (1998). "Ribonuclease A". Chem. Rev. 98 (3): 1045–1066. doi:10.1021/cr960427h. PMID 11848924.
- ^ "The Nobel Prize in Chemistry 1972". Nobelprize.org. Retrieved 10 February 2015.
- ^ "The Nobel Prize in Chemistry 1984". Nobelprize.org. Retrieved 10 February 2015.