Brevican

BCAN
Identifiers
Aliases	BCAN, BEHAB, CSPG7, Brevican
External IDs	OMIM: 600347; MGI: 1096385; HomoloGene: 7244; GeneCards: BCAN; OMA:BCAN - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	156,659,532 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	88,000,230 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; amygdala; ; anterior cingulate cortex; ; right frontal lobe; ; nucleus accumbens; ; caudate nucleus; ; putamen; ; ganglionic eminence; ; prefrontal cortex; ; Brodmann area 9;
	Top expressed in
	superior frontal gyrus; ; entorhinal cortex; ; primary visual cortex; ; perirhinal cortex; ; CA3 field; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex; ; central gray substance of midbrain; ; nucleus of stria terminalis; ; superior colliculus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	hyaluronic acid binding; carbohydrate binding; extracellular matrix structural constituent;
Cellular component	membrane; extracellular region; lysosomal lumen; Golgi lumen; anchored component of membrane; extracellular matrix; glutamatergic synapse;
Biological process	skeletal system development; chondroitin sulfate biosynthetic process; extracellular matrix organization; central nervous system development; chondroitin sulfate catabolic process; dermatan sulfate biosynthetic process; hippocampus development; cell adhesion; synapse maturation;
	Sources:Amigo / QuickGO
Orthologs
	63827
	12032
	ENSG00000132692
	ENSMUSG00000004892
	Q96GW7
	Q61361
	NM_021948; NM_198427
	NM_001109758; NM_007529
	NP_068767; NP_940819
	NP_001103228; NP_031555
	Wikidata
View/Edit Human	View/Edit Mouse

Brevican core protein is a protein that in humans is encoded by the BCAN gene.^[5]^[6]^[7] Brevican is a member of the lectican protein family.

Brevican is localised to the surface of neurons in the brain.^[8] In melanocytic cells, BCAN gene expression may be regulated by MITF.^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132692 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004892 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gary SC, Zerillo CA, Chiang VL, Gaw JU, Gray G, Hockfield S (Oct 2000). "cDNA cloning, chromosomal localization, and expression analysis of human BEHAB/brevican, a brain specific proteoglycan regulated during cortical development and in glioma". Gene. 256 (1–2): 139–47. doi:10.1016/S0378-1119(00)00362-0. PMID 11054543.
^ Nomoto H, Oohashi T, Hirakawa S, Ueki Y, Ohtsuki H, Ninomiya Y (Feb 2002). "Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23". Acta Medica Okayama. 56 (1): 25–9. PMID 11873941.
^ "Entrez Gene: BCAN brevican".
^ Frischknecht R, Seidenbecher CI (Jul 2012). "Brevican: a key proteoglycan in the perisynaptic extracellular matrix of the brain". The International Journal of Biochemistry & Cell Biology. 44 (7): 1051–4. doi:10.1016/j.biocel.2012.03.022. PMID 22537913.
^ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (Dec 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132692 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000004892 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11054543-5] Gary SC, Zerillo CA, Chiang VL, Gaw JU, Gray G, Hockfield S (Oct 2000). "cDNA cloning, chromosomal localization, and expression analysis of human BEHAB/brevican, a brain specific proteoglycan regulated during cortical development and in glioma". Gene. 256 (1–2): 139–47. doi:10.1016/S0378-1119(00)00362-0. PMID 11054543.

[pmid11873941-6] Nomoto H, Oohashi T, Hirakawa S, Ueki Y, Ohtsuki H, Ninomiya Y (Feb 2002). "Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23". Acta Medica Okayama. 56 (1): 25–9. PMID 11873941.

[entrez-7] "Entrez Gene: BCAN brevican".

[pmid22537913-8] Frischknecht R, Seidenbecher CI (Jul 2012). "Brevican: a key proteoglycan in the perisynaptic extracellular matrix of the brain". The International Journal of Biochemistry & Cell Biology. 44 (7): 1051–4. doi:10.1016/j.biocel.2012.03.022. PMID 22537913.

[pmid19067971-9] Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (Dec 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

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