Brian David Dynlacht

Brian David Dynlacht (born September 3, 1965 in Brooklyn, New York), is an American biochemist and professor in the department of pathology of New York University Grossman School of Medicine at NYU Langone Health.[1] Before moving his lab to New York University, he was an associate professor in the department of molecular and cellular biology at Harvard University. In 2002, while researching at the Harvard University, Dynlacht reported the discovery of CP110,[2] which is now thought to be at the center of a molecular switch governing the centriole to ciliary transition in mammalian cells.[3] His lab identified the first centriolar deubiquitinating enzyme, USP33, whose expression regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110, and thus regulates the centrosome duplication.[4][jargon]

  1. ^ "Brian D. Dynlacht".
  2. ^ Chen Z, Indjeian VB, McManus M, Wang L, Dynlacht BD (September 2002). "CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells". Dev. Cell. 3 (3): 339–50. doi:10.1016/S1534-5807(02)00258-7. PMID 12361598.
  3. ^ Spektor A, Tsang WY, Khoo D, Dynlacht BD (August 2007). "CP110 suppresses a cilia assembly program". Cell. 130 (4): 678–90. doi:10.1016/j.cell.2007.06.027. PMID 17719545. S2CID 17974875.
  4. ^ Li, J.; d'Angiolella, V.; Seeley, E. S.; Kim, S.; Kobayashi, T.; Fu, W.; Campos, E. I.; Pagano, M.; Dynlacht, B. D. (2013). "USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110". Nature. 495 (7440): 255–259. Bibcode:2013Natur.495..255L. doi:10.1038/nature11941. PMC 3815529. PMID 23486064.