Brian Thompson (born 1959) is an American actor.
Brian Thompson may also refer to:
- Brian B. Thompson, British writer
- Brian Thompson (footballer, born 1938) (1938–2011), English professional footballer and concert promoter
- Brian Thompson (footballer, born 1950), English professional footballer
- Brian Thompson (footballer, born 1952), English professional footballer
- Brian Thompson (sailor) (born 1962), British sailor
- Brian Thompson (businessman), CEO of UnitedHealthcare, insurance division of UnitedHealth