Bruton's tyrosine kinase

BTK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AWW, 1AWX, 1B55, 1BTK, 1BWN, 1K2P, 1QLY, 2GE9, 2Z0P, 3GEN, 3K54, 3OCS, 3OCT, 3P08, 3PIX, 3PIY, 3PIZ, 3PJ1, 3PJ2, 3PJ3, 4NWM, 4OT5, 4OT6, 4OTF, 4OTQ, 4OTR, 4RFY, 4RFZ, 4RG0, 4YHF, 4Z3V, 4ZLY, 4ZLZ, 5BPY, 5BQ0, 5FBN, 4RX5, 5FBO
Identifiers
Aliases	BTK, AGMX1, AT, ATK, BPK, IMD1, PSCTK1, XLA, Bruton tyrosine kinase, IGHD3
External IDs	OMIM: 300300; MGI: 88216; HomoloGene: 30953; GeneCards: BTK; OMA:BTK - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq22.1 Start 101,349,338 bp[1] End 101,390,796 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X E3|X 56.18 cM Start 133,443,085 bp[2] End 133,484,319 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte spleen bone marrow cells lymph node blood appendix epithelium of nasopharynx right lung upper lobe of left lung Top expressed in granulocyte spleen fetal liver hematopoietic progenitor cell mesenteric lymph nodes tibiofemoral joint blood bone marrow secondary oocyte zygote stroma of bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding nucleotide binding lipid binding signaling receptor binding identical protein binding protein kinase activity transferase activity kinase activity phosphatidylinositol-3,4,5-trisphosphate binding non-membrane spanning protein tyrosine kinase activity ATP binding protein binding protein tyrosine kinase activity Cellular component cytoplasm nucleus membrane membrane raft extrinsic component of cytoplasmic side of plasma membrane cytoplasmic vesicle cytosol plasma membrane perinuclear region of cytoplasm mast cell granule Biological process transmembrane receptor protein tyrosine kinase signaling pathway mesoderm development intracellular signal transduction peptidyl-tyrosine autophosphorylation B cell activation positive regulation of NF-kappaB transcription factor activity transcription, DNA-templated positive regulation of B cell differentiation B cell receptor signaling pathway Fc-epsilon receptor signaling pathway regulation of cell population proliferation adaptive immune response apoptotic process peptidyl-tyrosine phosphorylation protein phosphorylation negative regulation of cytokine production MyD88-dependent toll-like receptor signaling pathway apoptotic signaling pathway calcium-mediated signaling I-kappaB kinase/NF-kappaB signaling innate immune response regulation of transcription, DNA-templated cell maturation immune system process regulation of B cell cytokine production regulation of B cell apoptotic process phosphorylation histamine secretion by mast cell response to organic substance positive regulation of type III hypersensitivity protein autophosphorylation cellular response to reactive oxygen species cellular response to molecule of fungal origin positive regulation of type I hypersensitivity B cell affinity maturation negative regulation of B cell proliferation cellular response to interleukin-7 T cell receptor signaling pathway G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 695 12229 Ensembl ENSG00000010671 ENSMUSG00000031264 UniProt Q06187 P35991 RefSeq (mRNA) NM_001287345 NM_000061 NM_001287344 NM_013482 RefSeq (protein) NP_000052 NP_001274273 NP_001274274 NP_038510 Location (UCSC) Chr X: 101.35 – 101.39 Mb Chr X: 133.44 – 133.48 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Bruton's tyrosine kinase (abbreviated Btk or BTK), also known as tyrosine-protein kinase BTK, is a tyrosine kinase that is encoded by the BTK gene in humans. BTK plays a crucial role in B cell development.