C-Raf

RAF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1C1Y, 1FAQ, 1FAR, 1GUA, 1RFA, 3CU8, 3IQJ, 3IQU, 3IQV, 3KUC, 3KUD, 3NKX, 3O8I, 3OMV, 4FJ3, 4G0N, 4G3X, 4IEA, 4IHL
Identifiers
Aliases	RAF1, Raf-1 proto-oncogene, serine/threonine kinase, CMD1NN, CRAF, NS5, Raf-1, c-Raf
External IDs	OMIM: 164760; MGI: 97847; HomoloGene: 48145; GeneCards: RAF1; OMA:RAF1 - orthologs
Gene location (Mouse) Chr. Chromosome 6 (mouse)[1] Band 6 E3|6 53.62 cM Start 115,595,028 bp[1] End 115,653,596 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) n/a Top expressed in granulocyte epithelium of stomach zygote medullary collecting duct ventricular zone secondary oocyte ganglionic eminence temporal muscle triceps brachii muscle muscle of thigh BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding metal ion binding protein serine/threonine kinase activity small GTPase binding protein binding identical protein binding ATP binding kinase activity MAP kinase kinase kinase activity enzyme binding mitogen-activated protein kinase kinase binding adenylate cyclase binding adenylate cyclase activator activity protein heterodimerization activity Cellular component cytoplasm cytosol Golgi apparatus pseudopodium membrane plasma membrane mitochondrial outer membrane mitochondrion nucleus nuclear speck intracellular anatomical structure Biological process response to muscle stretch regulation of apoptotic process cell differentiation negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of protein phosphorylation intracellular signal transduction response to hypoxia somatic stem cell population maintenance phosphorylation thymus development cellular glucose homeostasis negative regulation of protein-containing complex assembly wound healing stimulatory C-type lectin receptor signaling pathway negative regulation of apoptotic process MAPK cascade positive regulation of peptidyl-serine phosphorylation regulation of cell motility platelet activation protein phosphorylation heart development thyroid gland development ion transmembrane transport face development death-inducing signaling complex assembly negative regulation of extrinsic apoptotic signaling pathway via death domain receptors intermediate filament cytoskeleton organization regulation of cell differentiation cell population proliferation regulation of Rho protein signal transduction signal transduction negative regulation of cell population proliferation positive regulation of transcription by RNA polymerase II insulin secretion involved in cellular response to glucose stimulus apoptotic process neurotrophin TRK receptor signaling pathway multicellular organism development negative regulation of signal transduction positive regulation of ERK1 and ERK2 cascade activation of adenylate cyclase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5894 110157 Ensembl ENSG00000132155 ENSMUSG00000000441 UniProt P04049 Q99N57 RefSeq (mRNA) NM_002880 NM_029780 NM_001356333 NM_001356334 RefSeq (protein) NP_002871 NP_001341618 NP_001341619 NP_001341620 NP_001341621 NP_001341622 NP_001341624 NP_001341623 NP_084056 NP_001343262 NP_001343263 Location (UCSC) n/a Chr 6: 115.6 – 115.65 Mb PubMed search [2] [3]
Wikidata
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RAF proto-oncogene serine/threonine-protein kinase, also known as proto-oncogene c-RAF or simply c-Raf or even Raf-1, is an enzyme^[4] that in humans is encoded by the RAF1 gene.^[5][6] The c-Raf protein is part of the ERK1/2 pathway as a MAP kinase (MAP3K) that functions downstream of the Ras subfamily of membrane associated GTPases.^[7] C-Raf is a member of the Raf kinase family of serine/threonine-specific protein kinases, from the TKL (Tyrosine-kinase-like) group of kinases.