C-reactive protein

CRP
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCRP, PTX1, C-reactive protein, pentraxin-related, C-Reactive Protein
External IDsOMIM: 123260; MGI: 88512; HomoloGene: 128039; GeneCards: CRP; OMA:CRP - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000567
NM_001329057
NM_001329058
NM_001382703

NM_007768

RefSeq (protein)

NP_000558
NP_001315986
NP_001315987
NP_001369632

NP_031794

Location (UCSC)Chr 1: 159.71 – 159.71 MbChr 1: 172.53 – 172.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

C-reactive protein (CRP) is an annular (ring-shaped) pentameric protein found in blood plasma, whose circulating concentrations rise in response to inflammation. It is an acute-phase protein of hepatic origin that increases following interleukin-6 secretion by macrophages and T cells. Its physiological role is to bind to lysophosphatidylcholine expressed on the surface of dead or dying cells (and some types of bacteria) in order to activate the complement system via C1q.[5]

CRP is synthesized by the liver[6] in response to factors released by macrophages, T cells and fat cells (adipocytes).[7] It is a member of the pentraxin family of proteins.[6] It is not related to C-peptide (insulin) or protein C (blood coagulation). C-reactive protein was the first pattern recognition receptor (PRR) to be identified.[8]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000132693Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037942Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Thompson D, Pepys MB, Wood SP (February 1999). "The physiological structure of human C-reactive protein and its complex with phosphocholine". Structure. 7 (2): 169–177. doi:10.1016/S0969-2126(99)80023-9. PMID 10368284.
  6. ^ a b Pepys MB, Hirschfield GM (June 2003). "C-reactive protein: a critical update". The Journal of Clinical Investigation. 111 (12): 1805–1812. doi:10.1172/JCI18921. PMC 161431. PMID 12813013.
  7. ^ Lau DC, Dhillon B, Yan H, Szmitko PE, Verma S (May 2005). "Adipokines: molecular links between obesity and atheroslcerosis". American Journal of Physiology. Heart and Circulatory Physiology. 288 (5): H2031–H2041. doi:10.1152/ajpheart.01058.2004. PMID 15653761.
  8. ^ Mantovani A, Garlanda C, Doni A, Bottazzi B (January 2008). "Pentraxins in innate immunity: from C-reactive protein to the long pentraxin PTX3". Journal of Clinical Immunology. 28 (1): 1–13. doi:10.1007/s10875-007-9126-7. PMID 17828584. S2CID 20300531.