C-type lectin

Lectin C-type domain
Pentameric structure of rattlesnake venom lectin which is a galactose binding lectin.[1] [2]
Identifiers
SymbolLectin_C
PfamPF00059
InterProIPR001304
SMARTCLECT
PROSITEPS50041
SCOP22msb / SCOPe / SUPFAM
CDDcd00037
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

A C-type lectin (CLEC) is a type of carbohydrate-binding protein known as a lectin.[3] The C-type designation is from their requirement for calcium for binding.[4] Proteins that contain C-type lectin domains have a diverse range of functions including cell-cell adhesion, immune response to pathogens and apoptosis.[5][6]

  1. ^ Walker JR, Nagar B, Young NM, Hirama T, Rini JM (April 2004). "X-ray crystal structure of a galactose-specific C-type lectin possessing a novel decameric quaternary structure". Biochemistry. 43 (13): 3783–92. doi:10.1021/bi035871a. PMID 15049685.
  2. ^ Mahla RS, Reddy MC, Prasad DV, Kumar H (September 2013). "Sweeten PAMPs: Role of Sugar Complexed PAMPs in Innate Immunity and Vaccine Biology". Frontiers in Immunology. 4: 248. doi:10.3389/fimmu.2013.00248. PMC 3759294. PMID 24032031.
  3. ^ Zelensky AN, Gready JE (December 2005). "The C-type lectin-like domain superfamily". FEBS J. 272 (24): 6179–217. doi:10.1111/j.1742-4658.2005.05031.x. PMID 16336259. S2CID 7084402.
  4. ^ C-Type+Lectin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
  5. ^ Drickamer K (October 1999). "C-type lectin-like domains". Curr. Opin. Struct. Biol. 9 (5): 585–90. doi:10.1016/S0959-440X(99)00009-3. PMID 10508765.
  6. ^ Cambi A, Figdor C (May 2009). "Necrosis: C-type lectins sense cell death". Curr. Biol. 19 (9): R375–8. Bibcode:2009CBio...19.R375C. doi:10.1016/j.cub.2009.03.032. PMID 19439262. S2CID 17409821.