CACNA2D2

CACNA2D2
Identifiers
Aliases	CACNA2D2, CACNA2D, calcium voltage-gated channel auxiliary subunit alpha2delta 2, CASVDD
External IDs	OMIM: 607082; MGI: 1929813; HomoloGene: 4400; GeneCards: CACNA2D2; OMA:CACNA2D2 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	50,504,244 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	107,406,542 bp
RNA expression pattern
	Top expressed in
	lower lobe of lung; ; cerebellar vermis; ; superior vestibular nucleus; ; ventral tegmental area; ; upper lobe of lung; ; upper lobe of left lung; ; right lung; ; vena cava; ; right hemisphere of cerebellum; ; gonad;
	Top expressed in
	lateral septal nucleus; ; habenula; ; trigeminal ganglion; ; substantia nigra; ; lateral hypothalamus; ; motor neuron; ; mammillary body; ; supraoptic nucleus; ; lobe of cerebellum; ; atrium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium channel activity; metal ion binding; voltage-gated ion channel activity; voltage-gated calcium channel activity;
Cellular component	voltage-gated calcium channel complex; integral component of membrane; membrane; plasma membrane;
Biological process	regulation of multicellular organism growth; regulation of insulin secretion; regulation of ion transmembrane transport; positive regulation of organ growth; ion transport; neuromuscular junction development; calcium ion transmembrane transport; rhythmic synaptic transmission; calcium ion transport; cardiac conduction;
	Sources:Amigo / QuickGO
Orthologs
	9254
	56808
	ENSG00000007402
	ENSMUSG00000010066
	Q9NY47
	Q6PHS9
	NM_001005505; NM_001174051; NM_001291101; NM_006030
	NM_001174047; NM_001174048; NM_001174049; NM_001174050; NM_020263
	NP_001005505; NP_001167522; NP_001278030; NP_006021
	NP_001167518; NP_001167519; NP_001167520; NP_001167521; NP_064659
	Wikidata
View/Edit Human	View/Edit Mouse

Voltage-dependent calcium channel subunit alpha2delta-2 is a protein that in humans is encoded by the CACNA2D2 gene.^[5]

This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.^[5]

CACNA2D2 containing channels are blocked by amiodarone.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000007402 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000010066 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2".
^ "Amiodarone". Drugbank. Retrieved 2019-05-28.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000007402 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000010066 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2".

[6] "Amiodarone". Drugbank. Retrieved 2019-05-28.

[1]

[2]

[3]

[4]

[5]

[6]