CAMP responsive element modulator

CREM
Identifiers
AliasesCREM, CREM-2, ICER, hCREM-2, cAMP responsive element modulator
External IDsOMIM: 123812; MGI: 88495; HomoloGene: 84591; GeneCards: CREM; OMA:CREM - orthologs
Orthologs
SpeciesHumanMouse
Entrez

1390

12916

Ensembl

ENSG00000095794

ENSMUSG00000063889

UniProt

Q03060

P27699

RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 10: 35.13 – 35.21 MbChr 18: 3.27 – 3.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

cAMP responsive element modulator is a protein that in humans is encoded by the CREM gene,[5][6][7] and it belongs to the cAMP-responsive element binding protein family. It has multiple isoforms, which act either as repressors or activators.[8] CREB family is important for in regulating transcription in response to various stresses, metabolic and developmental signals.[9] CREM transcription factors also play an important role in many physiological systems, such as cardiac function,[10] circadian rhythms,[11] locomotion and spermatogenesis.[12]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000095794 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000063889 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Meyer TE, Habener JF (November 1992). "Cyclic AMP response element binding protein CREB and modulator protein CREM are products of distinct genes". Nucleic Acids Research. 20 (22): 6106. doi:10.1093/nar/20.22.6106. PMC 334485. PMID 1461747.
  6. ^ Masquilier D, Foulkes NS, Mattei MG, Sassone-Corsi P (November 1993). "Human CREM gene: evolutionary conservation, chromosomal localization, and inducibility of the transcript". Cell Growth & Differentiation. 4 (11): 931–937. PMID 7916662.
  7. ^ "Entrez Gene: CREM cAMP responsive element modulator".
  8. ^ Foulkes NS, Sassone-Corsi P (February 1992). "More is better: activators and repressors from the same gene". Cell. 68 (3): 411–414. doi:10.1016/0092-8674(92)90178-f. PMID 1739963. S2CID 34290449.
  9. ^ Sassone-Corsi P (1995-01-01). "Transcription factors responsive to cAMP". Annual Review of Cell and Developmental Biology. 11: 355–377. doi:10.1146/annurev.cb.11.110195.002035. PMID 8689562.
  10. ^ Isoda T, Paolocci N, Haghighi K, Wang C, Wang Y, Georgakopoulos D, et al. (February 2003). "Novel regulation of cardiac force-frequency relation by CREM (cAMP response element modulator)". FASEB Journal. 17 (2): 144–151. doi:10.1096/fj.01-0981com. PMID 12554693. S2CID 17890025.
  11. ^ Sassone-Corsi P (June 2000). "CREM: a master-switch regulating the balance between differentiation and apoptosis in male germ cells". Molecular Reproduction and Development. 56 (2 Suppl): 228–229. doi:10.1002/(SICI)1098-2795(200006)56:2+<228::AID-MRD2>3.0.CO;2-B. PMID 10824972. S2CID 21160055.
  12. ^ Sassone-Corsi P (August 1998). "CREM: a master-switch governing male germ cells differentiation and apoptosis". Seminars in Cell & Developmental Biology. 9 (4): 475–482. doi:10.1006/scdb.1998.0200. PMID 9813195.