CBLB (gene)

CBLB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2AK5, 2BZ8, 2DO6, 2J6F, 2JNH, 2LDR, 2OOA, 2OOB, 3PFV, 3VGO, 3ZNI
Identifiers
Aliases	CBLB, Cbl-b, RNF56, Nbla00127, Cbl proto-oncogene B
External IDs	OMIM: 604491; MGI: 2146430; HomoloGene: 15856; GeneCards: CBLB; OMA:CBLB - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	105,869,552 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	52,028,411 bp
RNA expression pattern
	Top expressed in
	pericardium; ; epithelium of colon; ; Achilles tendon; ; tail of epididymis; ; saphenous vein; ; gastric mucosa; ; tibia; ; decidua; ; tibial nerve; ; visceral pleura;
	Top expressed in
	hand; ; genital tubercle; ; tail of embryo; ; umbilical cord; ; cumulus cell; ; renal corpuscle; ; lymph node; ; blood; ; left lung lobe; ; mesenteric lymph nodes;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; phosphotyrosine residue binding; metal ion binding; protein binding; ubiquitin-protein transferase activity; transferase activity; SH3 domain binding; receptor tyrosine kinase binding; ubiquitin protein ligase activity; zinc ion binding;
Cellular component	nucleoplasm; cytoplasm; cytosol; plasma membrane; membrane raft; nucleus;
Biological process	regulation of signaling; cell surface receptor signaling pathway; protein ubiquitination; NLS-bearing protein import into nucleus; signal transduction; proteolysis; epidermal growth factor receptor signaling pathway; negative regulation of epidermal growth factor-activated receptor activity; regulation of platelet-derived growth factor receptor-alpha signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	868
	208650
	ENSG00000114423
	ENSMUSG00000022637
	Q13191
	Q3TTA7
NM_170662; NM_001321786; NM_001321788; NM_001321789; NM_001321790;
	NM_001321791; NM_001321793; NM_001321794; NM_001321795; NM_001321796; NM_001321797; NM_001321798; NM_001321799; NM_001321806; NM_001321807; NM_001321808; NM_001321811; NM_001321813; NM_001321816; NM_001321820; NM_001321822; NM_004351
	NM_001033238
NP_001308715; NP_001308717; NP_001308718; NP_001308719; NP_001308720;
	NP_001308722; NP_001308723; NP_001308724; NP_001308725; NP_001308726; NP_001308727; NP_001308728; NP_001308735; NP_001308736; NP_001308737; NP_001308740; NP_001308742; NP_001308745; NP_001308749; NP_001308751; NP_733762
	NP_001028410
	Wikidata
View/Edit Human	View/Edit Mouse

CBL-B is an E3 ubiquitin-protein ligase that in humans is encoded by the CBLB gene.^[5]^[6] CBLB is a member of the CBL gene family.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000114423 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022637 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Keane MM, Rivero-Lezcano OM, Mitchell JA, Robbins KC, Lipkowitz S (July 1995). "Cloning and characterization of cbl-b: a SH3 binding protein with homology to the c-cbl proto-oncogene". Oncogene. 10 (12): 2367–77. PMID 7784085.
^ "Entrez Gene: CBLB Cas-Br-M (murine) ecotropic retroviral transforming sequence b".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000114423 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022637 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7784085-5] Keane MM, Rivero-Lezcano OM, Mitchell JA, Robbins KC, Lipkowitz S (July 1995). "Cloning and characterization of cbl-b: a SH3 binding protein with homology to the c-cbl proto-oncogene". Oncogene. 10 (12): 2367–77. PMID 7784085.

[6] "Entrez Gene: CBLB Cas-Br-M (murine) ecotropic retroviral transforming sequence b".

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