CBX5 (gene)

CBX5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3FDT, 3I3C
Identifiers
Aliases	CBX5, HEL25, HP1, HP1A, chromobox 5
External IDs	OMIM: 604478; MGI: 109372; HomoloGene: 7257; GeneCards: CBX5; OMA:CBX5 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.13 Start 54,230,942 bp[1] End 54,280,133 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 F3 Start 103,099,971 bp[2] End 103,148,243 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii caput epididymis corpus epididymis internal globus pallidus tail of epididymis retinal pigment epithelium ventricular zone mucosa of paranasal sinus ganglionic eminence entorhinal cortex Top expressed in tail of embryo maxillary prominence mandibular prominence genital tubercle somite hand epiblast abdominal wall ventricular zone Gonadal ridge More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity protein binding protein-macromolecule adaptor activity chromatin binding histone deacetylase binding methylated histone binding ribonucleoprotein complex binding protein-containing complex binding identical protein binding Cellular component kinetochore nucleus nuclear envelope pericentric heterochromatin nucleolus histone deacetylase complex nucleoplasm chromocenter heterochromatin chromosome, centromeric region histone methyltransferase complex transcription repressor complex chromosome PML body protein-containing complex ribonucleoprotein complex site of DNA damage Biological process blood coagulation negative regulation of transcription, DNA-templated viral process negative regulation of transcription by RNA polymerase II negative regulation of G0 to G1 transition cellular response to DNA damage stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23468 12419 Ensembl ENSG00000094916 ENSMUSG00000009575 UniProt P45973 Q61686 RefSeq (mRNA) NM_012117 NM_001127321 NM_001127322 NM_001076789 NM_001110216 NM_007626 NM_001358950 RefSeq (protein) NP_001120793 NP_001120794 NP_036249 NP_001070257 NP_001103686 NP_031652 NP_001345879 Location (UCSC) Chr 12: 54.23 – 54.28 Mb Chr 15: 103.1 – 103.15 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Chromobox protein homolog 5 is a protein that in humans is encoded by the CBX5 gene.^[5][6] It is a highly conserved, non-histone protein part of the heterochromatin family. The protein itself is more commonly called (in humans) HP1α.^{[citation needed]} Heterochromatin protein-1 (HP1) has an N-terminal domain that acts on methylated lysines residues leading to epigenetic repression.^[7] The C-terminal of this protein has a chromo shadow-domain (CSD) that is responsible for homodimerizing, as well as interacting with a variety of chromatin-associated, non-histone proteins.^[8]