CCAAT-enhancer-binding proteins

C/EBPα bZip domain bound to DNA. PDB entry 1nwq[1]

CCAAT-enhancer-binding proteins (or C/EBPs) is a family of transcription factors composed of six members, named from C/EBPα to C/EBPζ. They promote the expression of certain genes through interaction with their promoters. Once bound to DNA, C/EBPs can recruit so-called co-activators (such as CBP[2][3]) that in turn can open up chromatin structure or recruit basal transcription factors.

  1. ^ Miller M, Shuman JD, Sebastian T, Dauter Z, Johnson PF (Apr 2003). "Structural basis for DNA recognition by the basic region leucine zipper transcription factor CCAAT/enhancer-binding protein alpha". The Journal of Biological Chemistry. 278 (17): 15178–84. doi:10.1074/jbc.M300417200. PMID 12578822.
  2. ^ Kovács KA, Steinmann M, Magistretti PJ, Halfon O, Cardinaux JR (Sep 2003). "CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation". The Journal of Biological Chemistry. 278 (38): 36959–65. doi:10.1074/jbc.M303147200. PMID 12857754.
  3. ^ Ramji DP, Foka P (Aug 2002). "CCAAT/enhancer-binding proteins: structure, function and regulation". The Biochemical Journal. 365 (Pt 3): 561–75. doi:10.1042/BJ20020508. PMC 1222736. PMID 12006103.