CCL5

CCL5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1B3A, 1EQT, 1HRJ, 1RTN, 1RTO, 1U4L, 1U4M, 1U4P, 1U4R, 2L9H, 2VXW, 5CMD, 5DNF, 5COY
Identifiers
Aliases	CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP, C-C motif chemokine ligand 5
External IDs	OMIM: 187011; MGI: 98262; HomoloGene: 2244; GeneCards: CCL5; OMA:CCL5 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q12 Start 35,871,491 bp[1] End 35,880,793 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 C|11 50.66 cM Start 83,416,604 bp[2] End 83,421,344 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte blood lymph node spleen gallbladder duodenum epithelium of colon appendix bone marrow Top expressed in mesenteric lymph nodes spleen superior surface of tongue thymus blood jejunum duodenum subcutaneous adipose tissue Paneth cell right lung More reference expression data BioGPS More reference expression data
Gene ontology Molecular function CCR5 chemokine receptor binding receptor signaling protein tyrosine kinase activator activity chemokine activity protein self-association CCR4 chemokine receptor binding phosphatidylinositol phospholipase C activity protein kinase activity cytokine activity CCR1 chemokine receptor binding phospholipase activator activity chemokine receptor binding protein homodimerization activity chemokine receptor antagonist activity protein binding chemoattractant activity identical protein binding CCR chemokine receptor binding Cellular component cytoplasm extracellular region extracellular space Biological process leukocyte cell-cell adhesion positive regulation of cell-cell adhesion mediated by integrin regulation of T cell activation positive regulation of smooth muscle cell migration activation of phospholipase D activity negative regulation of viral genome replication positive regulation of ERK1 and ERK2 cascade positive regulation of innate immune response cellular response to interferon-gamma positive regulation of macrophage chemotaxis calcium ion transport exocytosis positive regulation of calcium ion transport response to cytokine regulation of insulin secretion chemokine-mediated signaling pathway positive regulation of cellular biosynthetic process response to virus positive regulation of monocyte chemotaxis cellular response to fibroblast growth factor stimulus neutrophil chemotaxis response to tumor necrosis factor negative regulation of T cell apoptotic process positive regulation of GTPase activity negative regulation of macrophage apoptotic process positive regulation of T cell proliferation positive regulation of phosphorylation inflammatory response positive regulation of translational initiation response to toxic substance positive regulation of epithelial cell proliferation positive regulation of tyrosine phosphorylation of STAT protein cellular response to organic cyclic compound cellular calcium ion homeostasis protein tetramerization chemotaxis positive regulation of homotypic cell-cell adhesion cellular response to interleukin-1 immune response positive regulation of viral genome replication positive regulation of receptor signaling pathway via JAK-STAT lipopolysaccharide-mediated signaling pathway positive regulation of T cell migration regulation of chronic inflammatory response positive regulation of smooth muscle cell proliferation neutrophil activation protein kinase B signaling positive regulation of cell migration positive regulation of natural killer cell chemotaxis cell-cell signaling eosinophil chemotaxis dendritic cell chemotaxis MAPK cascade macrophage chemotaxis positive regulation of T cell chemotaxis regulation of neuron death positive regulation of phosphatidylinositol 3-kinase signaling negative regulation of G protein-coupled receptor signaling pathway positive regulation of T cell apoptotic process positive regulation of cell adhesion negative regulation of chemokine-mediated signaling pathway monocyte chemotaxis positive chemotaxis positive regulation of protein tyrosine kinase activity cellular response to tumor necrosis factor positive regulation of activation of Janus kinase activity regulation of signaling receptor activity G protein-coupled receptor signaling pathway cytokine-mediated signaling pathway lymphocyte chemotaxis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6352 20304 Ensembl ENSG00000271503 ENSG00000274233 ENSMUSG00000035042 UniProt P13501 P30882 RefSeq (mRNA) NM_002985 NM_001278736 NM_013653 RefSeq (protein) NP_001265665 NP_002976 NP_038681 Location (UCSC) Chr 17: 35.87 – 35.88 Mb Chr 11: 83.42 – 83.42 Mb PubMed search [3] [4]
Wikidata
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Chemokine (C-C motif) ligand 5 (also CCL5) is a protein which in humans is encoded by the CCL5 gene.^[5] The gene has been discovered in 1990 by in situ hybridisation and it is localised on 17q11.2-q12 chromosome.^[6]

It is also known as RANTES (regulated on activation, normal T-cell expressed and secreted). RANTES was first described by Dr. Tom Schall who named the protein, the original source of the name Rantes was from the Argentine movie Man Facing Southeast about an alien who shows up in a mental ward who was named Rantés, the rather clunky acronym was only made to fit the name.^[7]