CCNB1IP1

CCNB1IP1
Identifiers
Aliases	CCNB1IP1, C14orf18, HEI10, cyclin B1 interacting protein 1
External IDs	OMIM: 608249; MGI: 2685134; HomoloGene: 18819; GeneCards: CCNB1IP1; OMA:CCNB1IP1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	20,333,312 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	51,045,189 bp
RNA expression pattern
	Top expressed in
	left ovary; ; ganglionic eminence; ; right ovary; ; gastric mucosa; ; cartilage tissue; ; ventricular zone; ; body of uterus; ; apex of heart; ; right auricle; ; left ventricle;
	Top expressed in
	epiblast; ; fetal liver hematopoietic progenitor cell; ; embryo; ; morula; ; spermatocyte; ; primitive streak; ; embryo; ; blastocyst; ; otic placode; ; primary oocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; metal ion binding; ubiquitin protein ligase activity; transferase activity;
Cellular component	condensed nuclear chromosome; synaptonemal complex; nucleus; chromosome;
Biological process	reciprocal meiotic recombination; chiasma assembly; meiosis; blastocyst formation; protein ubiquitination; spermatid development;
	Sources:Amigo / QuickGO
Orthologs
	57820
	239083
	ENSG00000100814
	ENSMUSG00000071470
	Q9NPC3
	D3Z3K2
	NM_182852; NM_021178; NM_182849; NM_182851
	NM_001111119
	NP_067001; NP_878269; NP_878272
	NP_001104589
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase CCNB1IP1 is an enzyme that in humans is encoded by the CCNB1IP1 gene.^[5]^[6]

HEI10 is a member of the E3 ubiquitin ligase family and functions in progression of the cell cycle through G(2)/M.[supplied by OMIM]^[6] It is considered a housekeeping gene.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100814 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000071470 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Toby GG, Gherraby W, Coleman TR, Golemis EA (Mar 2003). "A Novel RING Finger Protein, Human Enhancer of Invasion 10, Alters Mitotic Progression through Regulation of Cyclin B Levels". Mol Cell Biol. 23 (6): 2109–2122. doi:10.1128/MCB.23.6.2109-2122.2003. PMC 149478. PMID 12612082.
^ ^a ^b "Entrez Gene: CCNB1IP1 cyclin B1 interacting protein 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100814 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000071470 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12612082-5] Toby GG, Gherraby W, Coleman TR, Golemis EA (Mar 2003). "A Novel RING Finger Protein, Human Enhancer of Invasion 10, Alters Mitotic Progression through Regulation of Cyclin B Levels". Mol Cell Biol. 23 (6): 2109–2122. doi:10.1128/MCB.23.6.2109-2122.2003. PMC 149478. PMID 12612082.

[entrez-6] "Entrez Gene: CCNB1IP1 cyclin B1 interacting protein 1".

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