CCR4

CCR4
Identifiers
Aliases	CCR4, CC-CKR-4, CD194, CKR4, CMKBR4, ChemR13, HGCN:14099, K5-5, C-C motif chemokine receptor 4
External IDs	OMIM: 604836; MGI: 107824; HomoloGene: 21135; GeneCards: CCR4; OMA:CCR4 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	32,956,349 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	114,333,984 bp
RNA expression pattern
	Top expressed in
	testicle; ; appendix; ; lymph node; ; granulocyte; ; gallbladder; ; monocyte; ; blood; ; bone marrow cells; ; rectum; ; spleen;
	Top expressed in
	thymus; ; morula; ; embryo; ; lumbar subsegment of spinal cord; ; yolk sac; ; lip; ; blastocyst; ; meninges; ; spermatid; ; zone of skin;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	C-C chemokine receptor activity; G protein-coupled receptor activity; chemokine receptor activity; signal transducer activity; protein binding; chemokine binding; C-C chemokine binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; external side of plasma membrane; membrane; soma; intracellular anatomical structure;
Biological process	positive regulation of cytosolic calcium ion concentration; chemotaxis; chemokine-mediated signaling pathway; inflammatory response; neuron migration; homeostasis of number of cells; immune response; signal transduction; tolerance induction; response to bacterium; response to antibiotic; response to radiation; positive regulation of positive chemotaxis; G protein-coupled receptor signaling pathway; calcium-mediated signaling; cell chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	1233
	12773
	ENSG00000183813
	ENSMUSG00000047898
	P51679
	P51680
	NM_005508
	NM_009916
	NP_005499
	NP_034046
	Wikidata
View/Edit Human	View/Edit Mouse

C-C chemokine receptor type 4 is a protein that in humans is encoded by the CCR4 gene.^[5]^[6]^[7] CCR4 has also recently been designated CD194 (cluster of differentiation 194).

The protein encoded by this gene belongs to the G protein-coupled receptor family. It is a receptor for the following CC chemokines:

CCL2 (MCP-1)
CCL4 (MIP-1)
CCL5 (RANTES)
CCL17 (TARC)^[8]
CCL22 (Macrophage-derived chemokine)^[9]

Chemokines are a group of small structurally related proteins that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.^[7]

CCR4 is a cell-surface protein and should not be confused with the unrelated carbon catabolite repression-negative on TATA-less (CCR4-Not), a nuclear protein complex that regulates gene expression.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183813 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000047898 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Power CA, Meyer A, Nemeth K, Bacon KB, Hoogewerf AJ, Proudfoot AE, Wells TN (Sep 1995). "Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line". J Biol Chem. 270 (33): 19495–500. doi:10.1074/jbc.270.33.19495. PMID 7642634.
^ Samson M, Soularue P, Vassart G, Parmentier M (Feb 1997). "The genes encoding the human CC-chemokine receptors CC-CKR1 to CC-CKR5 (CMKBR1-CMKBR5) are clustered in the p21.3-p24 region of chromosome 3". Genomics. 36 (3): 522–6. doi:10.1006/geno.1996.0498. PMID 8884276.
^ ^a ^b "Entrez Gene: CCR4 chemokine (C-C motif) receptor 4".
^ Imai T, Baba M, Nishimura M, Kakizaki M, Takagi S, Yoshie O (June 1997). "The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4". J. Biol. Chem. 272 (23): 15036–42. doi:10.1074/jbc.272.23.15036. PMID 9169480.
^ Imai T, Chantry D, Raport CJ, Wood CL, Nishimura M, Godiska R, Yoshie O, Gray PW (January 1998). "Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4". J. Biol. Chem. 273 (3): 1764–8. doi:10.1074/jbc.273.3.1764. PMID 9430724.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000183813 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000047898 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7642634-5] Power CA, Meyer A, Nemeth K, Bacon KB, Hoogewerf AJ, Proudfoot AE, Wells TN (Sep 1995). "Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line". J Biol Chem. 270 (33): 19495–500. doi:10.1074/jbc.270.33.19495. PMID 7642634.

[pmid8884276-6] Samson M, Soularue P, Vassart G, Parmentier M (Feb 1997). "The genes encoding the human CC-chemokine receptors CC-CKR1 to CC-CKR5 (CMKBR1-CMKBR5) are clustered in the p21.3-p24 region of chromosome 3". Genomics. 36 (3): 522–6. doi:10.1006/geno.1996.0498. PMID 8884276.

[entrez-7] "Entrez Gene: CCR4 chemokine (C-C motif) receptor 4".

[pmid9169480-8] Imai T, Baba M, Nishimura M, Kakizaki M, Takagi S, Yoshie O (June 1997). "The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4". J. Biol. Chem. 272 (23): 15036–42. doi:10.1074/jbc.272.23.15036. PMID 9169480.

[pmid9430724-9] Imai T, Chantry D, Raport CJ, Wood CL, Nishimura M, Godiska R, Yoshie O, Gray PW (January 1998). "Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4". J. Biol. Chem. 273 (3): 1764–8. doi:10.1074/jbc.273.3.1764. PMID 9430724.

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