CD2

CD2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1CDB, 1GYA, 1HNF, 1L2Z, 1QA9, 2J6O, 2J7I
Identifiers
Aliases	CD2, LFA-2, SRBC, T11, CD2 molecule
External IDs	OMIM: 186990; MGI: 88320; HomoloGene: 1338; GeneCards: CD2; OMA:CD2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	116,769,229 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	101,195,255 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; thymus; ; lymph node; ; testicle; ; appendix; ; blood; ; epithelium of nasopharynx; ; superficial temporal artery; ; spleen; ; mucosa of ileum;
	Top expressed in
	thymus; ; mesenteric lymph nodes; ; spleen; ; blood; ; right lung lobe; ; subcutaneous adipose tissue; ; embryo; ; ankle joint; ; embryo; ; granulocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; protein binding; signaling receptor binding; signaling receptor activity; antigen binding; protein kinase binding; receptor tyrosine kinase binding; protein self-association;
Cellular component	integral component of membrane; membrane; cell-cell junction; anchored component of plasma membrane; integral component of plasma membrane; extracellular region; cell surface; cytoplasmic side of plasma membrane; external side of plasma membrane; plasma membrane; protein-containing complex; membrane raft;
Biological process	positive regulation of myeloid dendritic cell activation; heterotypic cell-cell adhesion; natural killer cell activation; membrane raft polarization; cell surface receptor signaling pathway; cell adhesion; positive regulation of tumor necrosis factor production; T cell activation; leukocyte migration; regulation of T cell differentiation; apoptotic process; cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	914
	12481
	ENSG00000116824
	ENSMUSG00000027863
	P06729; Q53F96
	P08920
	NM_001767; NM_001328609
	NM_013486
	NP_001315538; NP_001758; NP_001758.2
	NP_038514
	Wikidata
View/Edit Human	View/Edit Mouse

CD2 (cluster of differentiation 2) is a cell adhesion molecule found on the surface of T cells and natural killer (NK) cells. It has also been called T-cell surface antigen T11/Leu-5, LFA-2,^[5] LFA-3 receptor, erythrocyte receptor and rosette receptor.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116824 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027863 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sanchez-Madrid F, Krensky AM, Ware CF, Robbins E, Strominger JL, Burakoff SJ, Springer TA (1982). "Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3". Proc Natl Acad Sci U S A. 79 (23): 7489–93. Bibcode:1982PNAS...79.7489S. doi:10.1073/pnas.79.23.7489. PMC 347365. PMID 6984191.
^ Uniprot database entry for CD2 (accession number P06729)

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116824 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027863 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Sanchez-Madrid F, Krensky AM, Ware CF, Robbins E, Strominger JL, Burakoff SJ, Springer TA (1982). "Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3". Proc Natl Acad Sci U S A. 79 (23): 7489–93. Bibcode:1982PNAS...79.7489S. doi:10.1073/pnas.79.23.7489. PMC 347365. PMID 6984191.

[6] Uniprot database entry for CD2 (accession number P06729)

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