CD23

FCER2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFCER2, BLAST-2, CD23, CD23A, CLEC4J, FCE2, IGEBF, Fc fragment of IgE receptor II, FCErII, Fc epsilon receptor II
External IDsOMIM: 151445; MGI: 95497; HomoloGene: 1517; GeneCards: FCER2; OMA:FCER2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001207019
NM_001220500
NM_002002

RefSeq (protein)

NP_001193948
NP_001207429
NP_001993

Location (UCSC)Chr 19: 7.69 – 7.7 MbChr 8: 3.73 – 3.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CD23, also known as Fc epsilon RII, or FcεRII, is the "low-affinity" receptor for IgE, an antibody isotype involved in allergy and resistance to parasites, and is important in regulation of IgE levels. Unlike many of the antibody receptors, CD23 is a C-type lectin. It is found on mature B cells, activated macrophages, eosinophils, follicular dendritic cells, and platelets.

There are two forms of CD23: CD23a and CD23b. CD23a is present on follicular B cells, whereas CD23b requires IL-4 to be expressed on T-cells, monocytes, Langerhans cells, eosinophils, and macrophages.[5]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000104921Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005540Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lichtman AH, Abbas AK (2003). Cellular and molecular immunology. Philadelphia: Saunders. pp. 324–325. ISBN 0-7216-0008-5.