CD27

CD27
Identifiers
AliasesCD27, S152, S152. LPFS2, T14, TNFRSF7, Tp55, CD27 molecule
External IDsOMIM: 186711; MGI: 88326; HomoloGene: 74386; GeneCards: CD27; OMA:CD27 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001242

NM_001033126
NM_001042564
NM_001286753

RefSeq (protein)

NP_001233

NP_001028298
NP_001036029
NP_001273682

Location (UCSC)Chr 12: 6.44 – 6.45 MbChr 6: 125.21 – 125.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CD27 is a member of the tumor necrosis factor receptor superfamily.[5] It is currently of interest to immunologists as a co-stimulatory immune checkpoint molecule, and is the target of an anti-cancer drug in clinical trials.[6]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000139193Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030336Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Buchan SL, Rogel A, Al-Shamkhani A (January 2018). "The immunobiology of CD27 and OX40 and their potential as targets for cancer immunotherapy". Blood. 131 (1): 39–48. doi:10.1182/blood-2017-07-741025. PMID 29118006.
  6. ^ Sturgill ER (November 2017). "TNFR agonists: a review of current biologics targeting OX40, 4-1BB, CD27, and GITR". American Journal of Hematology/Oncology. 13 (11): 4–15.