CD32 (cluster of differentiation 32), also known as FcγRII or FCGR2, is a surface receptor glycoprotein belonging to the Ig gene superfamily.[2] CD32 can be found on the surface of a variety of immune cells.[2][3] CD32 has a low-affinity for the Fc region of IgG antibodies in monomeric form, but high affinity for IgG immune complexes.[4] CD32 has two major functions: cellular response regulation, and the uptake of immune complexes.[2] Cellular responses regulated by CD32 include phagocytosis, cytokine stimulation, and endocytic transport.[3] Dysregulated CD32 is associated with different forms of autoimmunity, including systemic lupus erythematosus.[5] In humans, there are three major CD32 subtypes: CD32A, CD32B, and CD32C. While CD32A and CD32C are involved in activating cellular responses, CD32B is inhibitory.[3]
^ abcLisi S, Sisto M, Lofrumento DD, D'Amore S, D'Amore M (March 2011). "Advances in the understanding of the Fc gamma receptors-mediated autoantibodies uptake". Clinical and Experimental Medicine. 11 (1): 1–10. doi:10.1007/s10238-010-0098-1. PMID20454994. S2CID6748965.
