CD33

CD33
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCD33, CD33 molecule, SIGLEC-3, SIGLEC3, p67
External IDsOMIM: 159590; MGI: 99440; HomoloGene: 88651; GeneCards: CD33; OMA:CD33 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001082618
NM_001177608
NM_001772

NM_001111058
NM_021293

RefSeq (protein)

NP_001076087
NP_001171079
NP_001763

NP_001104528
NP_067268

Location (UCSC)Chr 19: 51.23 – 51.24 MbChr 7: 43.17 – 43.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CD33 or Siglec-3 (sialic acid binding Ig-like lectin 3, SIGLEC3, SIGLEC-3, gp67, p67) is a transmembrane receptor expressed on cells of myeloid lineage.[5] It is usually considered myeloid-specific, but it can also be found on some lymphoid cells.[6]

It binds sialic acids, therefore is a member of the SIGLEC family of lectins.

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105383Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004609Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Garnache-Ottou F, Chaperot L, Biichle S, Ferrand C, Remy-Martin JP, Deconinck E, et al. (February 2005). "Expression of the myeloid-associated marker CD33 is not an exclusive factor for leukemic plasmacytoid dendritic cells". Blood. 105 (3): 1256–1264. doi:10.1182/blood-2004-06-2416. PMID 15388576.
  6. ^ Hernández-Caselles T, Martínez-Esparza M, Pérez-Oliva AB, Quintanilla-Cecconi AM, García-Alonso A, Alvarez-López DM, García-Peñarrubia P (January 2006). "A study of CD33 (SIGLEC-3) antigen expression and function on activated human T and NK cells: two isoforms of CD33 are generated by alternative splicing". Journal of Leukocyte Biology. 79 (1): 46–58. doi:10.1189/jlb.0205096. PMID 16380601. S2CID 21259300.