CD40 (protein)

CD40
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CZZ, 1D00, 1FLL, 1LB6, 3QD6, 5DMJ, 5IHL, 5DMI
Identifiers
Aliases	CD40, Bp50, CDW40, TNFRSF5, p50, CD40 (protein), CD40 molecule
External IDs	OMIM: 109535; MGI: 88336; HomoloGene: 954; GeneCards: CD40; OMA:CD40 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.12 Start 46,118,271 bp[1] End 46,129,863 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 H3|2 85.38 cM Start 164,897,547 bp[2] End 164,914,868 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lymph node right lung spleen upper lobe of left lung left ovary Descending thoracic aorta right ovary appendix gastric mucosa ascending aorta Top expressed in mesenteric lymph nodes spleen tail of embryo blood external carotid artery internal carotid artery semi-lunar valve thymus ascending aorta vas deferens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function antigen binding signal transducer activity protein binding tumor necrosis factor-activated receptor activity enzyme binding ubiquitin protein ligase binding protein domain specific binding signaling receptor activity Cellular component cytoplasm integral component of membrane intracellular membrane-bounded organelle membrane plasma membrane integral component of plasma membrane extracellular region cell surface CD40 receptor complex extracellular exosome external side of plasma membrane extracellular space soma varicosity Biological process positive regulation of protein phosphorylation positive regulation of MAP kinase activity positive regulation of interleukin-12 production protein kinase B signaling positive regulation of protein kinase C signaling immune system process cellular calcium ion homeostasis tumor necrosis factor-mediated signaling pathway immune response-regulating cell surface receptor signaling pathway platelet activation multicellular organism development B cell activation positive regulation of GTPase activity response to lipopolysaccharide B cell proliferation cellular response to mechanical stimulus positive regulation of endothelial cell apoptotic process regulation of cell population proliferation positive regulation of B cell proliferation positive regulation of NF-kappaB transcription factor activity defense response to virus immune response regulation of immune response positive regulation of I-kappaB kinase/NF-kappaB signaling apoptotic signaling pathway positive regulation of isotype switching to IgG isotypes cellular response to lipopolysaccharide positive regulation of transcription by RNA polymerase II defense response to protozoan response to bacterium response to nutrient levels response to cobalamin response to interferon-gamma cellular response to erythropoietin cellular response to interleukin-1 cellular response to tumor necrosis factor response to peptide inflammatory response positive regulation of tyrosine phosphorylation of STAT protein positive regulation of blood vessel endothelial cell migration positive regulation of angiogenesis protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 958 21939 Ensembl ENSG00000101017 ENSMUSG00000017652 UniProt P25942 P27512 RefSeq (mRNA) NM_001250 NM_001302753 NM_152854 NM_001322421 NM_001322422 NM_001362758 NM_011611 NM_170702 NM_170703 NM_170704 RefSeq (protein) NP_001241 NP_001289682 NP_001309350 NP_001309351 NP_690593 NP_001349687 NP_035741 NP_733803 NP_733804 NP_733805 Location (UCSC) Chr 20: 46.12 – 46.13 Mb Chr 2: 164.9 – 164.91 Mb PubMed search [3] [4]
Wikidata
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Cluster of differentiation 40, CD40 is a type I transmembrane protein found on antigen-presenting cells and is required for their activation. The binding of CD154 (CD40L) on T_H cells to CD40 activates antigen presenting cells and induces a variety of downstream effects.

Activated CD4+ T cells primarily exhibit its ligand CD40L/CD154 to antigen-presenting cells including dendritic cells (DCs), B cells, macrophages, classical and non-classical monocytes, on a variety of non-immune cells including platelets and endothelial cells, and on several types of tumor cells.^[5]

Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency.