CD44

CD44
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1POZ, 1UUH, 2I83, 4PZ3, 4PZ4
Identifiers
Aliases	CD44, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1, CD44 molecule (Indian blood group)
External IDs	OMIM: 107269; MGI: 88338; HomoloGene: 508; GeneCards: CD44; OMA:CD44 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	35,232,402 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	102,732,010 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; stromal cell of endometrium; ; vulva; ; gingival epithelium; ; skin of thigh; ; human penis; ; skin of abdomen; ; Achilles tendon; ; skin of hip; ; islet of Langerhans;
	Top expressed in
	molar; ; granulocyte; ; calvaria; ; dermis; ; submandibular gland; ; epithelium of lens; ; tibiofemoral joint; ; parotid gland; ; endothelial cell of lymphatic vessel; ; body of femur;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	collagen binding; protein binding; hyaluronic acid binding; cytokine receptor activity; transmembrane signaling receptor activity;
Cellular component	integral component of membrane; Golgi apparatus; macrophage migration inhibitory factor receptor complex; membrane; focal adhesion; plasma membrane; integral component of plasma membrane; cell surface; extracellular exosome; cytosol; secretory granule membrane; apical plasma membrane; lamellipodium membrane; cell projection; microvillus; basolateral plasma membrane;
Biological process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; monocyte aggregation; positive regulation of heterotypic cell-cell adhesion; hyaluronan catabolic process; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; interferon-gamma-mediated signaling pathway; extracellular matrix disassembly; extracellular matrix organization; negative regulation of apoptotic process; cellular response to fibroblast growth factor stimulus; positive regulation of peptidyl-serine phosphorylation; cartilage development; cell adhesion; negative regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of ERK1 and ERK2 cascade; positive regulation of peptidyl-tyrosine phosphorylation; cell-matrix adhesion; positive regulation of monocyte aggregation; leukocyte migration; neutrophil degranulation; wound healing, spreading of cells; regulation of lamellipodium morphogenesis; cell-cell adhesion; inflammatory response; cell migration; T cell activation; positive regulation of kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	960
	12505
	ENSG00000026508
	ENSMUSG00000005087
	P16070
	P15379
NM_000610; NM_001001389; NM_001001390; NM_001001391; NM_001001392;
	NM_001202555; NM_001202556; NM_001202557
NM_001039150; NM_001039151; NM_001177785; NM_001177786; NM_001177787;
	NM_009851
NP_000601; NP_001001389; NP_001001390; NP_001001391; NP_001001392;
	NP_001189484; NP_001189485; NP_001189486
NP_001034239; NP_001034240; NP_001171256; NP_001171257; NP_001171258;
	NP_033981
	Wikidata
View/Edit Human	View/Edit Mouse

The CD44 antigen is a cell-surface glycoprotein involved in cell–cell interactions, cell adhesion and migration. In humans, the CD44 antigen is encoded by the CD44 gene on chromosome 11.^[5] CD44 has been referred to as HCAM (homing cell adhesion molecule), Pgp-1 (phagocytic glycoprotein-1), Hermes antigen, lymphocyte homing receptor, ECM-III, and HUTCH-1.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000026508 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000005087 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Spring FA, Dalchau R, Daniels GL, Mallinson G, Judson PA, Parsons SF, et al. (May 1988). "The Ina and Inb blood group antigens are located on a glycoprotein of 80,000 MW (the CDw44 glycoprotein) whose expression is influenced by the In(Lu) gene". Immunology. 64 (1): 37–43. PMC 1385183. PMID 2454887.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000026508 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000005087 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2454887-5] Spring FA, Dalchau R, Daniels GL, Mallinson G, Judson PA, Parsons SF, et al. (May 1988). "The Ina and Inb blood group antigens are located on a glycoprotein of 80,000 MW (the CDw44 glycoprotein) whose expression is influenced by the In(Lu) gene". Immunology. 64 (1): 37–43. PMC 1385183. PMID 2454887.

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