CD46

CD46
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3O8E, 1CKL, 2O39, 3INB, 3L89, 5FO8
Identifiers
Aliases	CD46, AHUS2, MCP, MIC10, TLX, TRA2.10, CD46 molecule
External IDs	OMIM: 120920; MGI: 1203290; HomoloGene: 7832; GeneCards: CD46; OMA:CD46 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.2 Start 207,752,037 bp[1] End 207,795,513 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H6|1 98.41 cM Start 194,719,134 bp[2] End 194,774,557 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in palpebral conjunctiva seminal vesicula bronchial epithelial cell jejunal mucosa germinal epithelium parotid gland placenta right uterine tube right lung body of pancreas Top expressed in seminiferous tubule spermatid granulocyte vastus lateralis muscle intestinal villus primary visual cortex lumbar subsegment of spinal cord muscle of thigh ventricular zone embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function virus receptor activity cadherin binding protein binding complement binding endopeptidase activity enzyme inhibitor activity signaling receptor activity Cellular component integral component of membrane inner acrosomal membrane membrane focal adhesion plasma membrane integral component of plasma membrane cell surface extracellular exosome cytoplasmic vesicle acrosomal vesicle cytoplasm Golgi apparatus basolateral plasma membrane Biological process T cell mediated immunity adaptive immune response positive regulation of interleukin-10 production immune system process sequestering of extracellular ligand from receptor positive regulation of regulatory T cell differentiation negative regulation of gene expression single fertilization positive regulation of gene expression positive regulation of T cell proliferation positive regulation of memory T cell differentiation complement activation, classical pathway positive regulation of transforming growth factor beta production viral entry into host cell viral process regulation of Notch signaling pathway regulation of complement activation interleukin-10 production innate immune response proteolysis negative regulation of catalytic activity negative regulation of complement activation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4179 17221 Ensembl ENSG00000117335 ENSMUSG00000016493 UniProt P15529 O88174 RefSeq (mRNA) NM_002389 NM_153826 NM_172350 NM_172351 NM_172352 NM_172353 NM_172354 NM_172355 NM_172356 NM_172357 NM_172358 NM_172359 NM_172360 NM_172361 NM_010778 RefSeq (protein) NP_002380 NP_722548 NP_758860 NP_758861 NP_758862 NP_758863 NP_758869 NP_758871 NP_758865 NP_758866 NP_758867 NP_758868 NP_034908 Location (UCSC) Chr 1: 207.75 – 207.8 Mb Chr 1: 194.72 – 194.77 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CD46 complement regulatory protein also known as CD46 (cluster of differentiation 46) and Membrane Cofactor Protein is a protein which in humans is encoded by the CD46 gene.^[5] CD46 is an inhibitory complement receptor.^[6]