CD74

CD74
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A6A, 1ICF, 1IIE, 1L3H, 1MUJ, 3PDO, 3PGC, 3PGD, 3QXA, 3QXD, 4AEN, 4X5W
Identifiers
Aliases	CD74, DHLAG, HLADG, II, Ia-GAMMA, CD74 molecule, p33, CLIP
External IDs	OMIM: 142790; MGI: 96534; HomoloGene: 3209; GeneCards: CD74; OMA:CD74 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q33.1 Start 150,401,637 bp[1] End 150,412,969 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18 E1|18 34.41 cM Start 60,936,920 bp[2] End 60,945,724 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte appendix granulocyte spleen lymph node right lung gallbladder upper lobe of left lung lower lobe of lung mucosa of ileum Top expressed in spleen jejunum thymus ileum zone of skin colon lip uterus adrenal gland white adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nitric-oxide synthase binding identical protein binding MHC class II protein binding, via antigen binding groove cytokine receptor activity macrophage migration inhibitory factor binding protein folding chaperone activity MHC class II protein complex binding amyloid-beta binding protein binding MHC class II protein binding cytokine binding CD4 receptor binding Cellular component lysosomal lumen extracellular exosome MHC class II protein complex lysosomal membrane late endosome endocytic vesicle membrane transport vesicle membrane integral component of membrane ER to Golgi transport vesicle membrane multivesicular body Golgi apparatus Golgi membrane trans-Golgi network membrane macrophage migration inhibitory factor receptor complex membrane cell surface intracellular anatomical structure integral component of lumenal side of endoplasmic reticulum membrane endoplasmic reticulum endoplasmic reticulum membrane plasma membrane lysosome vacuole endosome clathrin-coated endocytic vesicle membrane NOS2-CD74 complex external side of plasma membrane Biological process immune response positive regulation of T cell differentiation negative regulation of apoptotic process signal transduction positive thymic T cell selection chaperone cofactor-dependent protein refolding T cell selection positive regulation of type 2 immune response positive regulation of dendritic cell antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II adaptive immune response antigen processing and presentation positive regulation of peptidyl-tyrosine phosphorylation negative regulation of mature B cell apoptotic process regulation of macrophage activation negative regulation of DNA damage response, signal transduction by p53 class mediator immunoglobulin mediated immune response leukocyte migration positive regulation of neutrophil chemotaxis positive regulation of chemokine (C-X-C motif) ligand 2 production macrophage migration inhibitory factor signaling pathway prostaglandin biosynthetic process cell population proliferation antigen processing and presentation of endogenous antigen immune system process defense response negative regulation of peptide secretion negative regulation of T cell differentiation positive regulation of macrophage cytokine production positive regulation of B cell proliferation negative thymic T cell selection positive regulation of fibroblast proliferation intracellular protein transport positive regulation of ERK1 and ERK2 cascade negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of cytokine-mediated signaling pathway positive regulation of protein phosphorylation positive regulation of kinase activity positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAPK cascade positive regulation of monocyte differentiation positive regulation of transcription, DNA-templated positive regulation of viral entry into host cell protein heterotetramerization protein trimerization protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 972 16149 Ensembl ENSG00000019582 ENSMUSG00000024610 UniProt P04233 P04441 RefSeq (mRNA) NM_004355 NM_001025158 NM_001025159 NM_001364083 NM_001364084 NM_001042605 NM_010545 RefSeq (protein) NP_001020329 NP_001020330 NP_004346 NP_001351012 NP_001351013 NP_001036070 NP_034675 Location (UCSC) Chr 5: 150.4 – 150.41 Mb Chr 18: 60.94 – 60.95 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

HLA class II histocompatibility antigen gamma chain also known as HLA-DR antigens-associated invariant chain or CD74 (Cluster of Differentiation 74), is a protein that in humans is encoded by the CD74 gene.^[5][6] The invariant chain (Abbreviated Ii) is a polypeptide which plays a critical role in antigen presentation. It is involved in the formation and transport of MHC class II peptide complexes for the generation of CD4+ T cell responses.^[7][8] The cell surface form of the invariant chain is known as CD74. CD74 is a cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF).^[9]