CD80

CD80
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1DR9, 1I8L
Identifiers
Aliases	CD80, B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7, CD80 molecule
External IDs	OMIM: 112203; MGI: 101775; HomoloGene: 3804; GeneCards: CD80; OMA:CD80 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q13.33 Start 119,524,293 bp[1] End 119,559,614 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 B4|16 26.86 cM Start 38,275,923 bp[2] End 38,316,697 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle lower lobe of lung pancreatic ductal cell tibialis anterior muscle appendix lymph node spleen upper lobe of lung upper lobe of left lung mucosa of ileum Top expressed in granulocyte stroma of bone marrow embryo thymus sternocleidomastoid muscle spleen vastus lateralis muscle blood endothelial cell of lymphatic vessel major salivary gland More reference expression data BioGPS n/a
Gene ontology Molecular function coreceptor activity virus receptor activity protein binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity Cellular component membrane cell surface external side of plasma membrane integral component of membrane plasma membrane intracellular anatomical structure protein complex involved in cell adhesion Biological process T cell costimulation intracellular signal transduction positive regulation of alpha-beta T cell proliferation cell-cell signaling positive regulation of signal transduction cellular response to lipopolysaccharide positive regulation of T-helper 1 cell differentiation viral process viral entry into host cell positive regulation of T cell proliferation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of transcription, DNA-templated T cell activation phosphatidylinositol phosphate biosynthetic process positive regulation of protein kinase B signaling immune response signal transduction cell surface receptor signaling pathway cytokine-mediated signaling pathway negative regulation of T cell proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 941 12519 Ensembl ENSG00000121594 ENSMUSG00000075122 UniProt P33681 Q00609 RefSeq (mRNA) NM_005191 NM_009855 NM_001359898 RefSeq (protein) NP_005182 NP_033985 NP_001346827 Location (UCSC) Chr 3: 119.52 – 119.56 Mb Chr 16: 38.28 – 38.32 Mb PubMed search [3] [4]
Wikidata
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The Cluster of differentiation 80 (also CD80 and B7-1) is a B7, type I membrane protein^[5] in the immunoglobulin superfamily, with an extracellular immunoglobulin constant-like domain and a variable-like domain required for receptor binding. It is closely related to CD86, another B7 protein (B7-2), and often works in tandem. Both CD80 and CD86 interact with costimulatory receptors CD28, CTLA-4 (CD152) and the p75 neurotrophin receptor.^[6][7]