CDKN1B

CDKN1B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2AST, 1H27, 1JSU
Identifiers
Aliases	CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1, cyclin-dependent kinase inhibitor 1B, cyclin dependent kinase inhibitor 1B
External IDs	OMIM: 600778; MGI: 104565; HomoloGene: 2999; GeneCards: CDKN1B; OMA:CDKN1B - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.1 Start 12,685,498 bp[1] End 12,722,369 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 G1|6 65.77 cM Start 134,897,364 bp[2] End 134,902,476 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in retinal pigment epithelium ventricular zone ganglionic eminence pons lateral nuclear group of thalamus trabecular bone parietal pleura superficial temporal artery germinal epithelium cerebellar vermis Top expressed in cerebellar vermis lobe of cerebellum blood pineal gland cumulus cell ventricular zone granulocyte habenula ganglionic eminence seminal vesicula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein phosphatase binding cyclin-dependent protein serine/threonine kinase activity protein kinase inhibitor activity protein kinase binding cyclin binding cyclin-dependent protein serine/threonine kinase inhibitor activity Hsp70 protein binding protein-containing complex binding chaperone binding Cellular component cytoplasm cytosol endosome nucleoplasm Cul4A-RING E3 ubiquitin ligase complex nucleus intracellular membrane-bounded organelle protein-containing complex Biological process Notch signaling pathway regulation of cyclin-dependent protein serine/threonine kinase activity DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest response to estradiol positive regulation of cell death response to hypoxia response to amino acid response to cadmium ion positive regulation of protein catabolic process response to organic cyclic compound cellular response to lithium ion cellular response to organic cyclic compound response to peptide hormone cell death negative regulation of apoptotic process hearing response to glucose potassium ion transport regulation of cell population proliferation negative regulation of cell growth negative regulation of epithelial cell proliferation involved in prostate gland development positive regulation of cell population proliferation positive regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of epithelial cell proliferation positive regulation of microtubule polymerization inner ear development cellular response to antibiotic cell cycle negative regulation of phosphorylation negative regulation of transcription, DNA-templated autophagic cell death negative regulation of cell population proliferation negative regulation of mitotic cell cycle negative regulation of kinase activity positive regulation of cell cycle negative regulation of vascular associated smooth muscle cell proliferation placenta development regulation of exit from mitosis regulation of lens fiber cell differentiation negative regulation of cyclin-dependent protein kinase activity negative regulation of cell cycle negative regulation of cyclin-dependent protein serine/threonine kinase activity G1/S transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1027 12576 Ensembl ENSG00000111276 ENSMUSG00000003031 UniProt P46527 P46414 RefSeq (mRNA) NM_004064 NM_009875 RefSeq (protein) NP_004055 NP_034005 Location (UCSC) Chr 12: 12.69 – 12.72 Mb Chr 6: 134.9 – 134.9 Mb PubMed search [3] [4]
Wikidata
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Cyclin-dependent kinase inhibitor 1B (p27^Kip1) is an enzyme inhibitor that in humans is encoded by the CDKN1B gene.^[5] It encodes a protein which belongs to the Cip/Kip family of cyclin dependent kinase (Cdk) inhibitor proteins. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. It is often referred to as a cell cycle inhibitor protein because its major function is to stop or slow down the cell division cycle.